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Azza Ahmed Mohamed Mahmoud

Basic information

Name : Azza Ahmed Mohamed Mahmoud
Title: Associate Professor of Pharmaceutical Technology
Google Schoolar Link: http://scholar.google.com/citations?user=5EoyTJ4AAAAJ&hl=en
Personal Info: Dr. Azza Ahmed Mahmoud; Associate Professor of Pharmaceutical Technology at Pharmaceutics and Pharmaceutical Technology Department. She holds MSc and PhD degrees in Pharmaceutics from Faculty of Pharmacy, Cairo University (Egypt) as well as Associate Professor degree from the National Research Center (Egypt). Azza received the Scientific Engorgement Award in Science of Pharmacy from the National Research Center for 2011 and got a certificate of appreciation for excellence in research output for 2011 from the National Research Center. Azza’s research is focused on the development of advanced drug delivery systems, such as biodegradable nanoparticles, transfersome, liposomes, chitosan nanoparticles, solid-lipid nanoparticles, liquid crystal nanoparticles, nanoemulsion and self-nanoemulsifying drug delivery systems. She co-authored 20 articles published in international journals and her work has been presented in more than 12 international conferences and workshops. She has guided 4 MSc students successfully and 7 candidates are registered under her supervision. View More...

Education

Certificate Major University Year
PhD Pharmaceutics Cairo University 2008
Masters Pharmaceutics Cairo University 2006
Bachelor Faculty of Pharmacy Cairo University 2002

Teaching Experience

Name of Organization Position From Date To Date
Department of Pharmaceutical Technology, National Research Center Research Staff Member 01/01/2003 06/05/2014

Researches /Publications

Brinzolamide loaded-polymeric nanoparticles - 01/0

Azza Ahmed Mohamed Mahmoud

Hamed A. Salama, M. Ghorab, Azza A. Mahmoud and Mayssa Abdel Hady

01/06/2016

The objective of the present study was to investigate the ability to formulate brinzolamide in the form of polylactic-co-glycolic acid (PLGA) nanoparticles. In this study brinzolamide-loaded nanoparticles were formulated according to the emulsification/solvent evaporation technique using the biodegradable PLGA. The effect of surfactant type and its percentage in the preparation were investigated. The investigated PLGA polymer with lactide: glycolide monomers’ ratio of 75:25 was able to develop PLGA vesicular system using the investigated surfactants. Brinzolamide-loaded nanoparticles prepared using PLGA with Pluronic acid F68 in the aqueous phase and 1 % Brij 97 in the organic phase showed the smallest particle size value (441.80 ± 72.97 nm). Brinzolamide-loaded nanoparticles prepared using PLGA with Pluronic acid F68 in aqueous phase and 2 % polysorbate 80 in organic phase had the largest encapsulation efficiency and drug loading values (47.86 ± 0.97 % and 38.76 %, respectively).

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Brinzolamide loaded-polymeric nanoparticles - 01/0

Azza Ahmed Mohamed Mahmoud

Hamed A. Salama, M. Ghorab, Azza A. Mahmoud and Mayssa Abdel Hady

01/06/2016

The objective of the present study was to investigate the ability to formulate brinzolamide in the form of polylactic-co-glycolic acid (PLGA) nanoparticles. In this study brinzolamide-loaded nanoparticles were formulated according to the emulsification/solvent evaporation technique using the biodegradable PLGA. The effect of surfactant type and its percentage in the preparation were investigated. The investigated PLGA polymer with lactide: glycolide monomers’ ratio of 75:25 was able to develop PLGA vesicular system using the investigated surfactants. Brinzolamide-loaded nanoparticles prepared using PLGA with Pluronic acid F68 in the aqueous phase and 1 % Brij 97 in the organic phase showed the smallest particle size value (441.80 ± 72.97 nm). Brinzolamide-loaded nanoparticles prepared using PLGA with Pluronic acid F68 in aqueous phase and 2 % polysorbate 80 in organic phase had the largest encapsulation efficiency and drug loading values (47.86 ± 0.97 % and 38.76 %, respectively).

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Nano spray drying technique as a novel approach to formulate stable econazole nitrate nanosuspension formulations for ocular use - 01/0

Azza Ahmed Mohamed Mahmoud

Maged, A., Mahmoud, A.A., Ghorab, M.M.

01/03/2016

The effect of using methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin as carriers for econazole nitrate nanoparticles prepared by nano spray dryer was explored in this work. Stabilizers, namely, poly(ethylene oxide), polyvinylpyrrolidone k30, poloxamer 407, Tween 80, and Cremophor EL, were used. The nano spray dried formulations revealed almost spherical particles with an average particle size values ranging from 121 to 1565 nm and zeta potential values ranging from −0.8 to −2.5 mV. The yield values for the obtained formulations reached 80%. The presence of the drug in the amorphous state within the nanosuspension matrix system significantly improved drug release compared to that for pure drug. Combination of hydroxypropyl-β-cyclodextrin with Tween 80 achieved an important role for preserving the econazole nanosuspension from aggregation during storage for one year at room temperature as well as improving drug release from the nanosuspension. This selected formulation was suspended in chitosan HCl to increase drug release and bioavailability. The in vivo evaluation on albino rabbit’s eyes demonstrated distinctly superior bioavailability of the selected formulation suspended in chitosan compared to its counterpart formulation suspended in buffer and crude drug suspension due to its mucoadhesive properties and nanosize. The nano spray dryer could serve as a one step technique toward formulating stable and effective nanosuspensions.

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Bioactive/natural polymeric scaffolds loaded with ciprofloxacin for treatment of osteomyelitis - 01/0

Azza Ahmed Mohamed Mahmoud

Amany A. Mostafa, Mayyada M.H. El-Sayed, Azza A. Mahmoud, Amira M. Gamal-Eldeen

01/02/2016

Local delivery of antibiotic into injured bone is a demand. In this work, different scaffolds of chitosan (C) with or without bioactive glass (G) were prepared using the freeze-drying technique in 2:1, 1:1 and 1:2 weight ratios. Chitosan scaffolds and selected formulas of chitosan/bioglass were loaded with ciprofloxacin in 5, 10 and 20% w/w. Scaffold morphology showed an interconnected porous structure, where the glass particles were homogeneously dispersed in the chitosan matrix. The kinetic study confirmed that the scaffold containing 1:2 weight ratio of chitosan:glass (CG12) showed optimal bioactivity with good compromise between Ca and P uptake capacities and Si release rate. Chitosan / bioactive glass scaffolds showed larger t50 values indicating less burst drug release followed by a sustained drug release profile compared to those of chitosan scaffolds. The cell growth, migration, adhesion, and invasion were enhanced onto CG12 scaffold surfaces. Samples of CG12 scaffolds with or without 5% drug induced vascular endothelial growth factor (VEGF), while those containing 10% drug diminished VEGF level. Only CG12 induced the cell differentiation (alkaline phosphatase activity). In conclusion, CG12 containing 5% drug can be considered a biocompatible carrier which would help in the localized osteomyelitis treatment.

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Design and in-vitro/in-vivo evaluation of ultra-thin mucoadhesive buccal film containing fluticasone propionate - 01/0

Azza Ahmed Mohamed Mahmoud

Ammar, H.O., Ghorab, M. and Mahmoud, A.A., Shahein, H.

01/02/2016

Fluticasone propionate is a synthetic corticosteroid drug distinguished by its potent anti-inflammatory action with low systemic side effects in comparison to other corticosteroids making it a potential drug for local buccal delivery. The aim of the present study was to design mucoadhesive buccal film containing fluticasone that is aesthetically acceptable and could maintain local drug release for a sustained period to manage the sign and symptoms of severe erosive mouth lesions. Solvent casting technique was used in film preparation. Different polymeric blends were used either alone or in combination with mucoadhesive polymers, sodium carboxymethyl cellulose (SCMC), or Carbopol 971P at different concentrations. The physicochemical properties, in vitro mucoadhesion time as well as the drug release properties for all prepared formulations were determined. Selected formulations with adequate properties were further examined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) and subjected to in vivo evaluation. Films containing hydroxypropyl methylcellulose (HPMC)/ethyl cellulose (EC) showed acceptable physicochemical properties, homogenous drug distribution, convenient mucoadhesion time, moderate swelling as well as sustained drug release up to 12 h. The biological performance of these formulations was assessed on healthy human volunteers and compared with a prepared mouthwash which showed enhanced pharmacokinetic parameters for the selected films in comparison to the mouthwash. The results revealed that the optimized formulation containing HPMC/EC and 10% SCMC could successfully achieve sustained drug release for 10 h which is considered promising for local treatment of severe mouth lesions.

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Awards

Award Donor Date
Certificate of appreciation for excellence in research output for 2011 from the National Center for Research National Research Center 2011
Scientific Engorgement Award in Science of Pharmacy from the National Research Center for 2011. National Research Center 2011

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