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Hanan Refaat

Basic information

Name : Hanan Refaat
Title: Professor of Pharmaceutical Organic chemistry, Vice Dean of Education and Student Affairs
Google Schoolar Link: http://scholar.google.com.eg/citations?user=PMHAZTAAAAAJ&hl=en
Personal Info: Professor Hanan Mohamed, professor of Pharmaceutical Organic Chemistry - Department of Pharmaceutical Chemistry, Vice Dean of education and student affairs. She has a Ph.D and a Master degree in Organic Chemistry from Cairo University. View More...

Education

Certificate Major University Year
PhD Pharmaceutical Sciences (Organic Chemistry) Faculty of Pharmacy, Cairo University 1997
Masters Pharmaceutical Sciences (Organic Chemistry) Faculty of Pharmacy, Cairo University 1991
Bachelor Pharmaceutical Sciences Faculty of Pharmacy, Cairo University 1985

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University Vice Dean of education and student affairs 01/01/2014 01/01/2016
Future University Head of Pharmaceutical Chemistry department 01/01/2013 01/01/2014
Faculty of Pharmacy, Cairo University Academic advisor of Clinical Pharmacy 01/01/2009 06/05/2014
Faculty of Pharmacy, Cairo University Head of the cumulative examination control 01/01/2009 06/05/2014
Faculty of Pharmacy, Cairo University Associate professor of Pharmaceutical Organic Chemistry 01/01/2007 06/05/2014
Faculty of Pharmacy, Cairo University Lecturer of Organic Chemistry 01/01/1997 01/01/2007
Faculty of Pharmacy, Cairo University Assistant Lecturer of Pharmaceutical Organic Chemistry 01/01/1990 01/01/1997
Faculty of Pharmacy, Cairo University Instructor of Pharmaceutical Organic Chemistry 01/01/1985 01/01/1991

Researches /Publications

Application of resin-bound reagents for the synthesis of benzimidazole derivatives - 01/0

Hanan Mohamed Refaat Khalil Elaassy

Ismail, M. Mohsen; Kamel, Mona M.; Nemr, M. Tawfik Mohamed

01/08/2016

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Solid-Phase Synthesis and Anti-Tumor Evaluation of Novel Benzimidazole Derivatives - 01/0

Hanan Mohamed Refaat Khalil Elaassy

Hanan M. Refaat* 1, Mohamed Mohsen Ismail 2, Mona Mounir Kamel 3, Mohamed Tawfeek Mohamed 3

01/09/2015

The benzimidazole skeleton, when selectively functionalized, is considered building block for the preparation of potent antineoplastic agents. 2- Substituted benzimidazole-5-carboxylic acids and 4- or 5- carboxylic acid derivatives that were used in the design of antineoplastic agents[1]. On the other hand, solid phase organic chemistry offers the opportunity of synthesizing molecules via novel routes, which may be difficult or impossible using traditional solution method[2][3]. In this work, we report an improved synthesis of selected novel 1,2- disubstituted benzimidazole-5-carboxylic acid analogues via solid phase to examine the feasibility of polymer-support method in synthesis of biologically active benzimidazoles. All of the synthesized compounds were docked on the active site of deoxyribonucleic acid to test their binding affinities. Furthermore, the synthesized compounds were subjected to preliminary screening of their antineoplastic activity.

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Hanan Mohamed Refaat Khalil Elaassy

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01/09/2015

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. - 01/0

Hanan Mohamed Refaat Khalil Elaassy

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01/02/2015

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Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno[2,3-d]pyrimidine and thieno[3,2-e] triazolo[4,3-c]pyrimidine derivatives. - 01/0

Hanan Mohamed Refaat Khalil Elaassy

M. M. Kandeel, Hanan M. Refaat, Asmaa E. Kassab, Inas G.Shahin and Tamer M. Abdelghany

01/01/2015

Motivated by the widely reported anticancer activity of thieno[2,3-d]pyrimidines a series of 24 new 2-substitutedhexahydrocycloocta[4,5] thieno[2,3-d]pyrimidines with different substituents at C-4 position and hexahydrocycloocta[4,5]thieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidines were synthesized. The anticancer activity of 17 compounds were evaluated by National Cancer Institute (USA) using a two stage process utilizing 59 different human tumor cell lines representing leukemia, melanoma, cancers of lung, colon, central nervous system (CNS), ovary, kidney, prostate as well as breast. Compound 9c showed broad spectrum potent anticancer activity in nano molar to micro molar range against 56 human tumor cell lines with GI50 less than 10 μM ranging from 0.495 to 5.57 μM, also it is worth mentioning that compound 9c had the marked highest selectivity against the two cell lines T-47D and MDA-MB-468 belonging to breast cancer with GI50 = 0.495 and 0.568 μM respectively, and its effect was further studied on cell cycle progression and induction of apoptosis in the MDA-MB-468 cell line. Results showed that compound 9c induced cell cycle arrest at G2/M phase and also, showed accumulation of cells in pre-G1 phase which may result from, degradation or fragmentation of the genetic materials indicating a possible role of apoptosis in compound 9c-induced cancer cell death and cytotoxicity and verifying this compound as promising selective anticancer lead. Compound 6c was selective against K-562, SR and MOLT-4 cell lines belonging to leukemia showing growth inhibition percentages 86.38, 65.76 and 60.40 at a single dose test, at the same time it showed lethal activity against HOP-92 representing non-small cell lung cancer. Interestingly, leukemia SR, CNS cancer SNB-75 and renal cancer UO-31 cell lines proved to be sensitive to compound 6d with growth inhibition percentages 52.86, 50.94 and 53.99 respectively. Additionally, compound 6d demonstrated lethal activity to HOP-92 belonging non-small cell lung cancer.

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Awards

Award Donor Date
The International Publication Award from Cairo University, for International publication. Cairo University 2013
The International Publication Award from Cairo University, for International publication. Cairo University 2012
The International Publication Award from Cairo University, for International publication. Cairo University 2011
The International Publication Award from Cairo University, for International publication. Cairo University 2008

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