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Manal Kandeel

Basic information

Name : Manal Kandeel
Title: Professor of Pharamceutical Organic Chemistry, Vice dean of Post Graduate and Research Affairs
Google Schoolar Link: http://scholar.google.com.eg/citations?user=U5dQnvQAAAAJ&hl=en
Personal Info: Professor Manal kandeel, Professor of Pharmaceutical Organic Chemistry - Department of Pharmaceutical Chemistry, Vice dean of Post Graduate and Research Affairs. She received her Ph.D. form Faculty of Pharmacy, Cairo University. Professor Manal was working as Vice Dean for Community Service and Environment Development, Faculty of Pharmacy, Cairo University, in 2011, the Faculty has been accredited by the National Authority for Quality Assurance and Accreditation of Education (NAQAAE). View More...

Education

Certificate Major University Year
PhD Organic Chemistry Cairo University 1987
Masters Organic Chemistry Cairo University 1982
Bachelor Pharmaceutical Sciences Cairo University 1976

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmacy, Cairo University Vice Dean for Post Graduate Studies and Research Affairs 01/10/2011 07/05/2014
Faculty of Pharmacy, Cairo University Acting Dean 01/09/2011 01/10/2011
Faculty of Pharmacy, Cairo University Acting Vice Dean for Post Graduate Studies and Research Affairs 01/08/2011 01/10/2011
Faculty of Pharmacy, Cairo University Vice Dean for Community Service and Environment Development 01/08/2009 01/10/2011
Faculty of Pharmacy, Beni-Suef University Head of Organic Chemistry Department 01/10/2005 01/06/2010
Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA) Head of Organic Chemistry Department 01/10/2004 01/03/2005
Faculty of Pharmacy, Cairo University Professor in Pharmaceutical Organic Chemistry Department 01/10/2003 06/05/2014
Faculty of Pharmacy, Cairo University Assistant Professor in Organic Chemistry Department 01/01/1993 01/01/2003
Faculty of Pharmacy, Cairo University Lecturer in Organic Chemistry Department 01/01/1987 01/01/1993
Faculty of Pharmacy, Cairo University Doctoral Candidate in Organic Chemistry Department 01/01/1982 01/01/1987
جامعة القاهرة كلية الصيدلة 06/11/1976 14/09/2013
Faculty of Pharmacy, Cairo University Researcher in Oraganic Chemistry Department 01/01/1976 01/01/1982

Researches /Publications

Synthesis and cytotoxic activity of acridine derivatives substituted with benzimidazole, benzoxazole and benzothiazole - 01/0

Manal Moustafa Hassan Kandeel

Sameeha M. Ali , Mohamed A. Abdelgawad, Mohamed Sadek

01/01/2016

Two novel series of 2-(Benzo[d]imidazole/oxazole/thiazole-2-yl))acridine-9(10H)-oneIVa-cand10-(2-((4- (Benzo[d]imidazole/oxazole/thiazole-2-yl)phenyl)amino)-2-oxoethyl)-9-oxo-9,10-dihydroacridine-4-carboxylic acidVIIa-cwere synthesized.The antitumor activity of the prepared compounds was evaluated against human breast cancer (MCF-7), hepatocellular carcinoma (HepG-2) and colon cancer (HCT-116) cell lines using Sulphorhodamine-B (SRB) assay method.Doxorubicin was used as a reference standard. Most of the tested compounds showed potent antitumor activity against HCT-116 cell line with IC50 range equal 4-31μM/mland the compoundVIIcwas the best active one (IC50 = 4.75 μM/ml). VIIashowed the same activity compared to the effect of the reference drug doxorubicin on Hep-2 cell line(IC50 = 3.75 μM/ml). Allof the tested compoundsshowed weak activity against MCF-7 cell line(IC50 = 5.01 μM/ml).

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Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno [2,3-d] pyrimidine and thieno [3,2-e] triazole [4,3-c] pyrimidine derivatives - 01/1

Manal Moustafa Hassan Kandeel

Manal M. Kandeel, Hanan M. Refaat, Asmaa E. Kassab, Inas G. Shahin, Tamer M. Abdelghany

01/12/2014

Motivated by the widely reported anticancer activity of thieno[2,3-d]pyrimidines a series of 24 new 2- substitutedhexahydrocycloocta[4,5] thieno[2,3-d]pyrimidines with different substituents at C-4 position and hexahydrocycloocta[4,5]thieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidines were synthesized. The anticancer activity of 17 compounds were evaluated by National Cancer Institute (USA) using a two stage process utilizing 59 different human tumor cell lines representing leukemia, melanoma, cancers of lung, colon, central nervous system (CNS), ovary, kidney, prostate as well as breast. Compound 9c showed broad spectrum potent anticancer activity in nano molar to micro molar range against 56 human tumor cell lines with GI50 less than 10 mM ranging from 0.495 to 5.57 mM, also it is worth mentioning that compound 9c had the marked highest selectivity against the two cell lines T-47D and MDA-MB-468 belonging to breast cancer with GI50 ¼ 0.495 and 0.568 mM respectively, and its effect was further studied on cell cycle progression and induction of apoptosis in the MDA-MB-468 cell line. Results showed that compound 9c induced cell cycle arrest at G2/M phase and also, showed accumulation of cells in pre-G1 phase which may result from, degradation or fragmentation of the genetic materials indicating a possible role of apoptosis in compound 9c-induced cancer cell death and cytotoxicity and verifying this compound as promising selective anticancer lead. Compound 6c was selective against K- 562, SR and MOLT-4 cell lines belonging to leukemia showing growth inhibition percentages 86.38, 65.76 and 60.40 at a single dose test, at the same time it showed lethal activity against HOP-92 representing non-small cell lung cancer. Interestingly, leukemia SR, CNS cancer SNB-75 and renal cancer UO-31 cell lines proved to be sensitive to compound 6d with growth inhibition percentages 52.86, 50.94 and 53.99 respectively. Additionally, compound 6d demonstrated lethal activity to HOP-92 belonging non-small cell lung cancer.

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Design, synthesis and cytotoxic activity of some novel compounds containing pyrazolo[3,4-d]pyrimidines nucleus - 01/0

Manal Moustafa Hassan Kandeel

SAMEHA M ROSHDY, EMAN K A ABDELALL, MOHAMED A ABDELGAWAD and PHOEBE F LAMIE

01/05/2013

Novel pyrazolo[3,4-d]pyrimidines were designed and synthesized as antitumour agents aganist human breast cancer adenoma (MCF-7). Molecular modelling and pharmcological screening were performed aganist breast cancer cell line and also certain synthetic pathways were developrd in order to introduce functionality onto C6 and C5 positions of pyrimidine moiety. Surprisingly, all the test compounds showed IC50 lower than that of the standard olomoucine I, especially compounds 4b, 8a, 10b, 11a and b, which showed IC50 between 0.009 and 0.004 uM

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Synthesis and In Vitro Antitumor Activity of Some New Mannich Bases - 01/0

Manal Moustafa Hassan Kandeel

Nadia A.Abdou , Hanan H.Kadry, Rana M.El-Masry

01/03/2013

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Awards

Award Donor Date
International Publication of Future University in Egypt Future University in Egypt 2015
International Publication of Cairo University Cairo University 2014
International Publication of Cairo University Cairo University 2013
International Publication of Cairo University Cairo University 2012

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