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Dalia Samuel

Basic information

Name : Dalia Samuel
Title: Professor of Pharmaceutical Sciences
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Personal Info: Prof. Dr. Dalia Samuel, professor of Pharmaceutics at Pharmaceutics and Pharmaceutical Technology Department. her doctoral research was performed at the University of Utah, USA with (distinguished) Prof. William I. Higuchi on transdermal drug delivery. Her post doctorate research was conducted at Oregon State University, Corvallis, Oregon, USA, on transdermal vaccines. View More...

Education

Certificate Major University Year
PhD Pharmaceutical Sciences University of Utah 2003
Masters Pharmaceutical Sciences Helwan University 2000
Bachelor Pharmaceutical Sciences Cairo University 1994

Teaching Experience

Name of Organization Position From Date To Date
FUE, Cairo, Egypt Professor of Pharmaceutics 01/01/2013 01/01/2016
Dept. of Pharmaceutics, Oregon State University, Corvallis, Oregon, USA Post doctorate candidate 01/01/2006 01/01/2007
Dept. of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA PhD student 01/01/2000 01/01/2002
Faculty of Pharmacy, Dept. of Pharmaceutics, Helwan University, Cairo, Egypt TA, Lecturer then Associate Professor of Pharmaceutics 01/01/1995 01/01/2013

Researches /Publications

Development of novel delivery system for nanoencapsulation of catalase: Formulation, characterization and in vivo evaluation using oxidative skin injury model. - 01/0

Dalia Samuel Shaker Kirolos

Heidi Mohamed Abdel Mageed, Afaf S. Fahmy, Dalia S. Shaker, Saleh A. Mohamed

01/01/2018

One of the main challenges for successful pharmaceutical application of Catalase (CAT) is maintaining its stability. Physical immobilization of CAT through nano-encapsulation was proposed to resolve this challenge. CAT encapsulating niosomes (e-CAT) were prepared using Brij® 30, 52, 76, 92, and 97 in presence of cholesterol (Ch) by thin film hydration method. Niosomes were characterized for encapsulation efficiency % (EE), size, poly-dispersity index (PI) and morphology. Kinetic parameters, pH optimum, thermal stability and reusability of CAT were determined. The influence of optimized e-CAT dispersion onto thermally injured rat skin was evaluated. Results revealed that encapsulation enhanced CAT catalytic efficiency (Vmax/ Km). Free CAT and e-CAT had pH optimum at 7.0. e-CAT exhibited improved thermal stability where it retained 50% residual activity at 60 ◦C. Free CAT lost its activity after 3 consecutive operational cycles however, e-CAT retained 60% of its initial activity following 12 cycles. After 24 hr of topical application on thermal injury, a significant difference in lesion size was observed with e-CAT compared to control group. Based on these encouraging results, CAT immobilization demonstrated a promising novel delivery system that enhances its operational stability. In addition, nano-encapsulated CAT can be anticipated to be beneficial in skin oxidative injury.

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Enhanced Transdermal Permeability of Terbinafine through Novel Nanoemulgel Formulation; Development, In vitro and In vivo Characterization - 01/0

Dalia Samuel Shaker Kirolos

Maha E. Elmataeeshy , Magda S. Sokar , Mohamed Bahey El-Din , Dalia S. Shaker.

01/07/2017

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Topically applied liposomal DNA for transcutaneous immunization" - 01/0

Dalia Samuel Shaker Kirolos

01/02/2017

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In situ thermosensitive Tamoxifen citrate loaded hydrogels: an effective tool in breast cancer loco-regional therapy. - 01/0

Dalia Samuel Shaker Kirolos

Dalia S. Shaker, Mohamed A. Shaker, Mahmoud S. Hanafy.

01/07/2016

One of the main challenges for using Tamoxifen citrate (TMC) in breast cancer therapy is achieving proper target and efficient delivery of adequate concentration to the adenocarcinoma without harming healthy glandular and soft fatty tissue. Herein, TMC niosomal thermosensitive hydrogels were proposed as a tool to resolve this challenge. Niosomes were prepared by film hydration technique and incorporated into Pluronics thermosensitive gels prepared using cold method. The prepared hydrogels were evaluated for gelation temperature, rheological behavior and in vitro drug release. Moreover, in vivo anti-tumor activity was examined in Ehrlich carcinoma mice model through reporting solid tumor volume regression and tissue distribution of TMC. Type and ratio of used poloxamers were manipulated to provide the optimal gelation temperature (34e37 C). Rheological analysis showed low viscosity and elasticity values at low and room temperature while these values significantly increased at the physiological temperature. A prolonged diffusion-driven release of TMC was detected. In vivo data showed, evidently, that anticancer activity was improved with significant retention of the drug at the tumor site. These encouraging results confined that this in situ hydrogel depot offers an attractive approach for controlled delivery of TMC and clinically expected to be useful delivery system in loco-regional therapy for breast cancer.

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loco-regional breast cancer therapy through in situ thermosensitive Tamoxifen citrate niosomal gels. - 01/0

Dalia Samuel Shaker Kirolos

Dalia Samuel Shaker, Mohamed A. Shaker, Mahmoud S. Hanafy

01/03/2016

Loco-regional delivery of Tamoxifen Citrate (TMC) is used in this study to localize its activity into the vicinity of tumor and hence improving therapeutic outcome with less toxicity on other organs. Herein, innovative TMC niosomal thermosensitive gels were proposed as a tool to achieve this goal. Niosomes were prepared by thin lipid film hydration technique and evaluated for cellular uptake and cytotoxicity. The anti-cancer activity was also tested in-vitro using MCF-7 breast cancer cell line. Moreover, in-vivo anti-tumor efficacy was examined in Ehrlich carcinoma mice model through reporting solid tumor volume regression and tissue TMC distribution. Significantly enhanced cellular uptake (2.8 fold) and greater cytotoxic activity with MCF-7 breast cancer cell line were obtained from vesicles prepared with span 60: cholesterol (1:1 molar ratio). Niosomes were then packed in thermosensitive gels using cold method. TMC niosomal thermosensitive gels were evaluated for gelation temperature, rheological behavior and in vitro drug release. Type and ratio of used poloxamers were manipulated to provide an optimal gelation temperature (34-37°C). Rheological analysis showed low viscosity and elasticity values at low temperature while these values significantly increased at elevated physiological temperature. A prolonged release of TMC following a diffusion-driven release model was detected. Furthermore, in vivo data showed evidently that anticancer activity was improved with significant retention of the drug at the tumor site. These encouraging results confined that this in situ gel depot offers an attractive approach for controlled delivery of TMC and clinically expected to be useful candidate in breast cancer loco-regional therapy.

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Awards

Award Donor Date
Editorial Board member of Future Journal of Pharmaceutical Sciences, Elsevier FUE 2015
AAPS membership AAPS organization, USA 2000

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