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Mona El Assal

Basic information

Name : Mona El Assal
Title: Associat Professor of Pharmaceutics at Pharmaceutics and Pharmaceutical Technology department at FUE University.
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Personal Info: Dr. Mona Ebrahim. Associat Professor of Pharmaceutics at Pharmaceutics and Pharmaceutical Technology department.She got her Master and Doctoral degree from Cairo University View More...

Education

Certificate Major University Year
PhD Pharmaceutics and Clinical Pharmacy. Cairo University 2005
Masters Pharmaceutics and Clinical Pharmacy. Cairo University. 2000
Bachelor Pharmaceutical Sciences Cairo University 1984

Teaching Experience

Name of Organization Position From Date To Date
Military Medical Academy Consultant of Army Pharmaceutical Industry and Lecturer 01/01/1992 01/01/2011

Researches /Publications

Effect of Tinidazole on Norfloxacin Disposition - 01/1

Mona Ebrahim Abdel Tawab Ahmed Elassal

Mona Ibrahim Abdel tawab ElAssal and sally Ali Helmy

01/11/2017

Co-administration of norfloxacin (NFX) and tinidazole (TNZ) has been used for the treatment of gastrointestinal and urinary tract infections. Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. The present study was undertaken to investigate the effect of TNZ at the usual clinical dosage on the pharmacokinetics of NFX in healthy volunteers. This study was conducted as an open-label, randomized, two-way crossover experimental design. After an overnight fast, subjects were randomized to receive a single oral dose of NFX 400 mg alone and the fixed-dose combination (FDC) of NFX /TNZ 400 mg/600mg on two different occasions separated by 1 week washout period between treatments. Blood samples were collected up to 24 h postdose, and plasma was analyzed for NFX concentrations by using HPLC. The pharmacokinetic properties of NFX after FDC administration were compared with NFX administered alone. Twelve healthy subjects were enrolled (6 in each part), and all subjects completed the study. None of the participants showed any sign of adverse drug reactions during or after the completion of the study. The 90% confidence interval (CI) between NFX alone and when co-administered with TNZ indicated the presence of an interaction between NFX and TNZ, which would significantly increase the systemic rate and exposure of NFX absorption. The co-administration of TNZ with NFX increased the AUC and Cmax of NFX significantly compared with administration of NFX alone. The AUC and Cmax of NFX alone were 6.0 μg.hr/ mL (2.3-9.8) and 0.87 μg/mL (0.4-1.6), respectively whereas the corresponding AUC and Cmax values after administration of FDC were 7.1 μg.hr/mL (4.0-10.6) and 0.97 μg/mL (0.4-1.7), respectively. The respective geometric mean ratios of NFX for AUC and Cmax with TNZ were 1.197 [90% CI, 0.941-1.522] and 1.087 (90% CI, 0.807 -1.463) compared with NFX alone. Both Tmax and Ka of NFX showed a significant decrease after administration of the combination compared to administration of NFX alone. The peak plasma concentration reached at 1.3 h (0.6-2.4) and 1.9 h (0.4-4.4) after oral administration of FDC and NFX alone, respectively. Both NFX and TNZ were well tolerated. The interaction of TNZ with fluroquinolones should be investigated to determine whether this interaction is limited to NFX or if other fluroquinolones have the same pharmacokinetic interactions. Further studies are necessary to determine the role of P-gp and other transporters on NFX disposition and pharmacokinetics. Additionally, the influence of TNZ on the physiological activity of GIT should be investigated.

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Olmesartan medoxomil-loaded mixed micelles: Preparation, - 01/1

Mona Ebrahim Abdel Tawab Ahmed Elassal

Mohamed A. El-Gendy a, Mona I.A. El-Assal a, *, Mina Ibrahim Tadros b,

01/10/2017

Olmesartan medoxomil (OLM) is highly lipophilic in nature (log p ¼ 4.31) which attributes to its low aqueous solubility contributing to its low bioavailability 25.6%. OLM was loaded into mixed micelles carriers in a trial to enhance its solubility, thus improving its oral bioavailability. OLM-loaded mixed micelles were prepared, using a Pluronic® mixture of F127 and P123, adopting the thin-film hydration method. Three drug: Pluronic® mixture ratios (1:40, 1:50and 1: 60) and various F127: P123 ratios were prepared. OLM Loaded mixed micelles showed stability up to 12 h. The particle size of the systems varied from 364.00 nm (F3) to 13.73 nm (F18) with accepted Poly dispersity index (PDI) values. The in-vitro release studies of OLM from mixed micelles versus drug aqueous suspension were assessed using the reverse dialysis technique in a USP Dissolution tester apparatus (type II). The highest RE% (43%) was achieved with OLM-loaded mixed micelles (F8) when compared to (35%) of drug suspension. © 2017 Future University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

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ACYCLOVIR – LOADED SOLID LIPID NANOPARTICLE BASED CREAM: A NOVEL - 01/0

Mona Ebrahim Abdel Tawab Ahmed Elassal

Mona Ibrahim Abdel Tawab El-assal

01/03/2017

Background Topical treatment of skin diseases needs to be strategic to ensure high drug concentration in the skin with minimum systemic absorption. The present investigation was enthused by the possibility to develop solid lipid nanoparticles (SLNs) of hydrophilic drug acyclovir. Also study vitro and vivo drug delivery. Methods: Acyclovir loaded solid lipid nanoparticles were prepared by high pressure homogenization of aqueous surfactant solutions containing the drug-loaded lipids in the melted or in the solid state with formula optimization study. Acyclovir loaded solid lipid nanoparticles were incorporated in cream base. The pH was evaluated and rheological study. Drug release was evaluated and compared with drug based on simple cream. Also the release of acyclovir loaded solid lipid nanoparticles conjugate with compritol 888ATO was compared with marketed cream. The potential of solid lipid as the carrier for dermal delivery was studied. Results: Particle size analysis of SLNs prove small, smooth, spherical shape particle ranged from 150 to 200 nm for unloaded and from 330 to 444 nm for acyclovir loaded particles. The EE% for optimal formula is 72% with suitable pH for skin application. Rheological behavior is shear thinning and thixotropic. Release study proved controlled drug release especially in formula containing compritol88 ATO. Stability study emphasized an insignificant change in the particles properties over 6 month. Invivo study showed significantly higher accumulation of acyclovir in stratum corneum compared with blank skin. Conclusion: acyclovir loaded solid lipid nanoparticles might be beneficial in controlling drug release, stable and improving dermal delivery of antiviral agent(s)

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Formulation, Optimization, and Evaluation of Solid Dispersions of metformin HCl Using Factorial Design - 01/1

Mona Ebrahim Abdel Tawab Ahmed Elassal

Mona El Assal, Mohammed mannaa, Ahmed Abdel Bary,

01/12/2016

ABSTRACT The objective of this study is to achieve the controlling dissolution rate of Metformin HCl, a freely water soluble antidiabetic drug. Solid dispersions microcapsules were prepared using solvent evaporation method which enclosed preparation of a uniform dispersion of Metformin HCl in (Hydroxy propyl methylcellulose k100, Ethyl cellulose, Eudragit RL PO, RS PO & Compritol 888 ATO). A two-factor, General factorial statistical design was used to quantitate the effect of polymer type (X1) and drug: polymer ratio(X2) on the release profile. Where polymer type and drug: polymer ratio were selected as independent variables, while Y1 (cumulative drug release after 1 hr. ) and Y2 (cumulative drug release in 3 hrs. ), Y3 (cumulative drug release in 10 hrs.),Y4 (angle of repose ) and Y5 (Hausner ratio) were selected as dependent variables. The solid dispersions were characterized for their in vitro- release rate. The optimized formulation was further characterized by Drug scanning calorimetry, infrared spectrophotometry, X-Ray Diffractometer and SEM analysis. A convenient statistical model was made and a significantly controlled release rate was exhibited .the optimized formulation was investigated by DSC, XRD, FTIR and SEM data which showed the crystalline nature of Metformin HCl in a solid dispersion, the statistical model helped us to recognize the effects of formulation variables on the dispersion. Keywords: Metformin HCl, Solid dispersion, controlled release, factorial design, HPMC k 100, Ethyl cellulose, Eudragit RL, RS& Compritol ATO 888.

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Gelatine Based Nanoparticles as Drug Delivery System of Lornoxicam Gel - 01/1

Mona Ebrahim Abdel Tawab Ahmed Elassal

01/10/2016

Abstract: The purpose of contemporary study was to project GNP by using of two step desolvation method. Biodegradable hydrophilic gelatin nanoparticles used as a delivery system of anti-inflammatory lornoxicam after gel formulation using each of hydroxyl propyl methyl cellulose (HPMC) and carbopol as gelling agent. The size and shape of the nanoparticles were examined by optical microscope and transmission electron microscopy, particles with a mean diameter of 240.6 nm and 0.1 poly dispersibility index PDI were produced and the percentage of entrapment efficiency was found to be 87.1%. The optimum amount of LOR loading was obtained. Four formulas were prepared F1 standard LOR carbopol gel, F2 standard LOR HPMC gel, F3 GNP –LOR containing carbopol as gelling agent and F4 GNP –LOR which has HPMC as gelling agent are GNP-LOR gel. Permeation of drug through membrane was determined by Franz diffusion cell. Further stability studies were carried out at 4Co for a period of 8 weeks. Vivo study was carried on white albino male rats to compare between different lornoxicam gel formulations. Conclusion: Results show that the two step desolvation is an appropriate method for preparing GNP. LORF3 which has carbopol as gelling agent was of lower release rate with maximum % inhibition of edema.

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Awards

Award Donor Date
Certificate of Excellence Meletary Medical Services 2005

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