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khairia M. Youssef

Basic information

Name : khairia M. Youssef
Title: Professor of Pharmaceutical Organic Chemistry
Google Schoolar Link: http://scholar.google.com.eg/citations?user=WVhMlB4AAAAJ&hl=en
Personal Info: Professor Khairia Youssef, Professor of Organic Chemistry, Department od Pharmaceutical Chemistry. • Dr. Khairia had the Bachelor of Pharmaceutical Sciences, the Master degree and Ph.D. in Organic Chemistry from Faculty of Pharmacy, Cairo University on 1977, 1980 and 1984, respectively. • On 1988, Dr. Khairia was on a special research assignment with Etreby Computer in Los Angeles, California, U.S.A. • On 1992, Dr. Khairia was on a Peace Fellowship for Post Doctoral Research which concerns with "Design and Synthesis of Potential Antileukemic and/or Antiviral 2'-Deoxymethylene Nucleosides" at the University of Southern California, Los Angeles, California. U.S.A., under the supervision of Dr. Eric J. Lien, Ph. D. The design of the work is based on QSAR. • Prof. Dr. Youssef is interested in drug design, synthesis and evaluation of certain pharmacologically active compounds. Prof. Youssef had been awarded the Bronze award from King Abdul Aziz city for science and technology for the exclusive research “Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents” which had been granted by King Abdul Aziz city for science and technology, Project No. AR 19-39. Prof. Youssef had been awarded a certificate from The Marquis Who's who Publications Board as a subject of biographical record in Who's who in Science and Engineering 2008-2009. Inclusion in which is limited to those individuals who have demonstrated outstanding achievement in their own fields of endeavor and who have, thereby, contributed significantly to the betterment of contemporary society. She had been awarded the silver award from King Abdul Aziz city for science and technology for the exclusive research “Novel Modified Estrogens: Synthesis, Binding Affinity to Estrogen Receptor, Biological and Antitumor Activities of various Novel Modified Estrogen” which had been granted by King Abdul Aziz city for science and technology, Project No. AR 24-4. Prof. Youssef had been awarded the FUE Azazi Award for Outstanding Research for the academic year 2012/2013. This reflects well on the important contributions to the scholarly reputation of FUE. Perzigian, Anthony (perzigaj) PERZIGAJ@UCMAIL.UC.EDU Prof. Youssef as an International Conference Organizer had been awarded a Certificate for Participating as Organizer for the 1st FUE International Conference on Pharmaceutical Technologies (1st FUE-ICPT), Feb, 2012.http://icpt.fue.edu.eg/ Also, Prof. Youssef had been awarded a Certificate for Participating as Organizer for 3rd FUE International Conference of Pharmaceutical Sciences (3rd FUE-ICPS), Feb, 9-11, 2015. http://www.fue.edu.eg/pharmaconference. Finally, Prof. Youssef was informed that the organizing committee of OMICS International Pharma Middle East Conference November 02-04, 2014, Dubai, UAE are pleased to join them and give a keynote presentation on: Targeted Drug Delivery System (TDDS): Encapsulating Newly Synthesized Anti-cancer Compounds-Conjugated Gold Nanoparticles Also, she was informed that the selection committee has decided to be one of the Conference Organizing Committee. www.conferenceseries.com View More...

Education

Certificate Major University Year
PhD Pharmaceutical Organic chemistry Cairo University 1984
PhD Pharmaceutical Organic Chrmistry Faculty of Pharmacy, Cairo University 1984
Masters Organic Chemistry Cairo University 1980
Bachelor Pharmaceutical Sciences Cairo University 1977

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt Professor of Pharmaceutical Organic Chemistry 01/01/2007 01/01/2016
Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt Professor of Pharmaceutical Organic Chemistry 01/01/2007 01/01/2015
Faculty of Pharmacy, King Saud University, K.S.A. Professor at the Pharmaceutical Chemistry Department 01/01/2005 01/01/2007
College of Pharmacy, Science and Medical studies Department, King Saud University, K.S.A. Head of Pharmaceutical Chemistry Department 01/01/2002 01/01/2005
Faculty of Pharmacy, King Saud University Professor at Pharmaceutical Chemistry Department 01/01/1999 01/01/2002
Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Saud University Associate Professor 01/01/1994 01/01/1999
Faculty of Pharmacy, Cairo University Assistant Professor at the Organic Chemistry Department 01/01/1992 01/01/1994
Faculty of Pharmacy, Cairo University Assistant Professor at the Organic Chemistry Department 01/01/1989 01/01/1991

Researches /Publications

Curcumin Analogs with anticipated anticancer activityIten M. Fawzy1, Khairia M. Youssef¬¬1, Nasser S. M. Ismail2, J. Gullbo3 and Khaled A. M. Abouzid¬2.1Pharmaceutical chemistry Dept. Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University, Cairo, 12311, Egypt. - 01/1

Khairia Mohamed Ahmed Youssef

01/12/2015

Six novel curcumin analogs were designed, synthesized with 3,5-dibenzylidenepiperidin-4-one core moiety and three of them were evaluated for their antitumor activities in 5 different cell lines; [ovarian cancer (A2780), renal adenocarcinoma (ACHN), prostate cancer (PC-3), colorectal cancer (Hct-116) and a leukemic monocyte lymphoma (U937-GTB)]. Also in silico molecular docking was performed on the six curcumin analogs to predict their binding affinity to tubulin enzyme and their ability to destabilize microtubules through interaction energy docking scores compared to that of podophyllotoxin. Three of newly synthesized compounds were tested in vitro for their effect on tubulin polymerization.

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Design and synthesis of potential Ribonucleotide reductase enzyme (RNR) inhibitors as antileukemic and/or antiviral 2'-Deoxymethylene Nucleosides - 01/1

Khairia Mohamed Ahmed Youssef

Prof. Dr. Eric J. Lien

01/12/2015

In order to improve the antitumor and/or antiviral activities of existing nucleoside analogs, eight new compounds (9a,b, 14a,b, 15a,b and 16a,b) were designed and synthesized. Halogen atom were incorporated at the 2-position of the purine base to render the amino group at the 6-position less susceptible to metabolism by adenosine deaminase. A methylene group was introduced at the 2'-position following the lead of nucleoside antibiotics angustmycin A and neplanocin A. The two key intermediates 9a and 9b were prepared from guanosine after protection of the 3' and 5' hydroxyl groups and oxidation of the 2' hydroxyl group to the corresponding carbonyl group using swern method. The conversion of the carbonyl group to the methylene function was carried out by applying wittig reaction conditions. The final compounds 14 a,b, 15 a,b, 16 a,b were prepared by means of nonaqueous diazotization of 9a and 9b. The prepared compounds were subjected to in vitro antileukemic and antiviral activity upon a new L1210 cell line that is doubly resistant to both hydroxyurea and deoxyadenosine which was grown and characterized. The new compounds showed potent antileukemic activity.

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Chemopreventive Effects of Curcumin Analogs in DMH-Induced Colon Cancer in Albino Rats Model. - 01/0

Khairia Mohamed Ahmed Youssef

01/01/2015

Synthesis and preclinical safety evaluation in mice and rats of Curcumin (1) and curcumin analogs (2, 3) were done. Besides, the chemopreventive effects in DMH-induced colon cancer in albino rats model were performed. Sections of mammary gland, heart, kidney, liver, spleen, and colon were done. Administration of the prophylactic treatment for four weeks before the induction of cancer by DMH, showed that compound 3 is the most active one. Chemopreventive treatment with different forms of curcumin extracts for 2 and 4 weeks caused a reduction in the number of aberrant crypt foci (ACF) especially compound 3. Chemopreventive treatment with different forms of curcumin extracts for 2 and 4 weeks caused a reduction in the number of tumor cells.

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Targeted Drug Delivery System (TDDS): Encapsulating Newly Synthesized Anti-cancer Compounds-Conjugated Gold Nanoparticles - 01/0

Khairia Mohamed Ahmed Youssef

Khairia M. Youssef¬¬1, Nasser S. M.

01/01/2015

Targeted drug delivery system(TDDS) is the most important research field for the design and development of pharmaceutical drugs. The basic premise of a TDDS is to concentrate the drug in the tissues of interest while reducing the relative concentration of medication in other remaining tissues [1, 2]. As a result, the drug is localized to a greater degree on the targeted site while leaving surrounding tissues unaffected. The ideal drug delivery system delivers drug at rates finely tuned to the biological requirement of the body sign and development [3, 4]. The significant advantage with TDDS includes protecting the payload and improving therapeutic index [4-6]. TDDS has several advantages for the treatment of disease quantitatively. For instance, drug localization, decreased side effects, reduced dosage, modulated pharmacokinetics, controlled bio-distribution, and most importantly, improved patient's compliance [7, 8]. In this context, TDDS, especially gold-based nanoparticles (AuNPs) will be used as a model system in this work. The main objective and basic principle behind the concept of targeting is that, the specific drug receptor is targeted to fit and improve their binding affinity, to the specific receptor that ultimately will trigger the pharmacological activity [9].

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Design and synthesis of potential Ribonucleotide reductase enzyme (RNR) inhibitors as antileukemic and/or antiviral 2'-Deoxymethylene Nucleosides - 01/0

Khairia Mohamed Ahmed Youssef

Eric J. Lien

01/01/2015

In order to improve the antitumor and/or antiviral activities of existing nucleoside analogs, eight new compounds (9a,b, 14a,b, 15a,b and 16a,b) were designed and synthesized. Halogen atom were incorporated at the 2-position of the purine base to render the amino group at the 6-position less susceptible to metabolism by adenosine deaminase. A methylene group was introduced at the 2'-position following the lead of nucleoside antibiotics angustmycin A and neplanocin A. The two key intermediates 9a and 9b were prepared from guanosine after protection of the 3' and 5' hydroxyl groups and oxidation of the 2' hydroxyl group to the corresponding carbonyl group using swern method. The conversion of the carbonyl group to the methylene function was carried out by applying wittig reaction conditions. The final compounds 14a,b, 15a,b, 16a,b were prepared by means of nonaqueous diazotization of 9a and 9b. The prepared compounds were subjected to in vitro antileukemic and antiviral activity upon a new L1210 cell line that is doubly resistant to both hydroxyurea and deoxyadenosine which was grown and characterized. The new compounds showed potent antileukemic activity.

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Awards

Award Donor Date
AZAZI FUE Award for Outstanding Research Future University in Egypt 2013
the Bronze award from King Abdul Aziz city for science and technology for the exclusive research “Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents” which had been granted by King Abdul Aziz city for science and technology, Project No. AR 19-39. King Abdul Aziz city for science and technology 2010
D. Walid Bin Amin El-Kayaly For Scintific Research award- Saudy Pharmaceutical Syndicate, for the research titled: Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs. El-Kayaly For Scintific Research award- Saudy Pharmaceutical Syndicate, Saudi Arabia 2010
A certificate from The Marquis Who's who Publications Board as a subject of biographical record in Who's who in Science and Engineering 2008-2009. Who's who in Science and Engineering, USA 2009
the silver award from King Abdul Aziz city for science and technology for the exclusive research King Abdul Aziz city for science and technology, Saudi Arabia 2008

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