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Yasmin Saad

Basic information

Name : Yasmin Saad
Title: Assistant Lecturer
Google Schoolar Link: http://scholar.google.com.eg/citations?mauthors=yasmine+abulfadl&hl=ar&view_op=search_authors
Personal Info: Assistant Lecturer: Yasmin Saad, Assistant Lecturer in Pharmacology and Toxicology and Biochemsitry deptartment. She has got her Masters degree from Helwan University.

Education

Certificate Major University Year
Masters Pharmaceutical Sciences Helwan University 2009
Bachelor Pharmacy Helwan University 2005

Teaching Experience

Name of Organization Position From Date To Date
Pfizer Trainee 01/01/2010 01/01/2011

Researches /Publications

Non Classical Antifolates, Part 5. Benzodiazepine Analogs as a New Class of DHFR Inhibitors: Synthesis, Antitumor Testing and Molecular Modeling Study - 01/0

Yasmin Saad Abulfadl Okasha

01/01/2014

A new series of tetrahydro quinazoline and tetrahydro 1H dibenzo diazepine analogs were synthesized and tested for their DHFR inhibition and in vitro antitumor activity. Compound 35 showed a remarkable DHFR inhibitory potency which is twenty fold more active than methotrexate (MTX). Compounds 17 and 23 proved to be fifteen fold more active than the known antitumor 5 FU, with MG MID GI50, TGI and LC50 values of 1.5, 46.8, 93.3 and 1.4, 17.4, 93.3 respectively. Computer modeling studies allowed the identification that methoxy and methyl substituents, the system of the chalcone core, the nitrogen atoms, on the dibenzodiazepine ring as pharmacophoric features essential for activity. These mark points could be used as template model for further future optimization.

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Nonclassical antifolates, Part 4. 5-(2-Aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study. - 01/0

Yasmin Saad Abulfadl Okasha

01/01/2013

A new series of tetrahydro-quinazoline and tetrahydro-1H-dibenzo[b,e][1,4]diazepine analogues were synthesized and tested for their DHFR inhibition and in- vitro antitumor activity. Compound 35 showed a remarkable DHFR inhibitory potency (IC50, 0.004 μM) which is twenty fold more active than methotrexate (MTX). Compounds 17 and 23 proved to be fifteen fold more active than the known antitumor 5-FU, with MG-MID GI50, TGI, and LC50 values of 1.5, 46.8, 93.3 and 1.4, 17.4, 93.3 μM, respectively. Computer modeling studies allowed the identification that methoxy and methyl substituents, the π-system of the chalcone core, the nitrogen atoms, on the dibenzodiazepine ring as pharmacophoric features essential for activity. These mark points could be used as template model for further future optimization.

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Nonclassical antifolates, part 5. Benzodiazepine analogues as a new class of DHFR inhibitors: Synthesis, antitumor testing and molecular modeling study☆ - 01/0

Yasmin Saad Abulfadl Okasha

01/01/2013

A new series of tetrahydro-quinazoline and tetrahydro-1H-dibenzo[b,e][1,4]diazepine analogues were synthesized and tested for their DHFR inhibition and in- vitro antitumor activity. Compound 35 showed a remarkable DHFR inhibitory potency (IC50, 0.004 μM) which is twenty fold more active than methotrexate (MTX). Compounds 17 and 23 proved to be fifteen fold more active than the known antitumor 5-FU, with MG-MID GI50, TGI, and LC50 values of 1.5, 46.8, 93.3 and 1.4, 17.4, 93.3 μM, respectively. Computer modeling studies allowed the identification that methoxy and methyl substituents, the π-system of the chalcone core, the nitrogen atoms, on the dibenzodiazepine ring as pharmacophoric features essential for activity. These mark points could be used as template model for further future optimization.

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ICPT - 01/0

Yasmin Saad Abulfadl Okasha

01/01/2012

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Effect of nigella sativa oil constituents on colon cancer - 01/0

Yasmin Saad Abulfadl Okasha

01/01/2010

Effect of nigella sativa oil constituents on colon cancer egyptian society of toxicology

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Awards

Award Donor Date
Ideal Student helwan university 2003

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