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Staff Researches

Yousra Mohamed Sabry

Cardiac disorders and mode of action of the Egyptian scorpion venom Androctonus bicolor on isolated toad’s heart

Yousra Mohamed Sabry Ahmed Abdelmottaleb

Mohamed A. Abdel-Rahmana, , , Aya S. Ayeda, Yousra Abdel-Mottaleb, Mohamed Alaa A. Omrana, Zohour I. Nabila

The Journal of Basic & Applied Zoology

2015

Scorpion venom is a complex mixture of components with various pharmacological and toxicological effects. It is characterized by the presence of a large number of toxins that specifically interact with ion channels of excitable cells. The Egyptian scorpion Androctonus bicolor belongs to the family of Buthidae and until now no information is available about the effect of its venom on cardiac muscles. Using an in vitro approach, cardiotoxicity and mode of action of A. bicolor venom on isolated toad’s heart were investigated. Direct application of scorpion venom (0.5 μg/ml) into isolated toad’s heart induced a remarkable bradycardia concomitant with a protraction in the conduction time (P–R interval). In the meantime, a significant increase in the R-wave amplitude (ventricular contraction) was noticed after 5 min of venom perfusion. Various cases of cardiac disorders were recorded such as sinus arrhythmias, ectopic beats and different degrees of heart block. Through using different autonomic and ion channel blockers, the possible mechanism of action of A. bicolor venom on isolated toad’s heart was revealed. The application of both atropine (4 μg/ml) and verapamil (5 μg/ml) could not alleviate the pronounced negative chronotropic and positive inotropic effects. Meanwhile, a significant decrease in the R-wave amplitude was observed after propranolol (5 μg/ml) application. In conclusion, our findings indicate that the venom of A. bicolor directly influenced the cardiac electrical activity of toads through β-adrenergic receptors. The direct effect of this venom on cardiac tissues may significantly contribute in the development of several cardiotoxic effects following scorpion sting.

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Molecular Modeling Studies of Some Uracil and New Deoxyuridine Derivatives

Yousra Mohamed Sabry Ahmed Abdelmottaleb

M. S. A. Abdel-Mottaleb2

Journal of Chemistry

2016

Molecular modeling results reported in this paper are crucial in highlighting the quantitative relationship between the optimized structure and computed molecular properties related to four newly synthesized uracil derivatives with promising biological potential as anticancer bioactive agents. Moreover, 5-fluorouracil (5-FU) and its tautomers and thiouracils molecular properties are studied and correlated with their biological activities. The great medical importance of these and similar molecular systems requires research on their quantitative structure-activity relationships (QSAR) in order to further improve our knowledge about how receptor binding, selectivity, and pharmacological effects are achieved. Modeling is performed in the ground and the first singlet excited states using density functional theory (DFT) and its time-dependent extension (TD-DFT), respectively.

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Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily.

Yousra Mohamed Sabry Ahmed Abdelmottaleb

2012

Vandendriessche T, Kopljar I, Jenkins DP, Diego-Garcia E, Abdel-Mottaleb Y, Vermassen E, Clynen E, Schoofs L, Wulff H, Snyders D, Tytgat J. Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24.

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1. Bito V, deWaard MC, Biesmans L, Lenaerts I, Ozdemir S, Abdel-Mottaleb Y, Driesen R, Holemans P, Duncker DJ, Sipido K. Early exercise training after myocardial infarction prevents contractile but not electrical remodeling or hypertrophy. Cardiovasc Res. 2010 Jan 6; 86(1):72-81.

Yousra Mohamed Sabry Ahmed Abdelmottaleb

Cardiovascular research

2010

1. Bito V, deWaard MC, Biesmans L, Lenaerts I, Ozdemir S, Abdel-Mottaleb Y, Driesen R, Holemans P, Duncker DJ, Sipido K. Early exercise training after myocardial infarction prevents contractile but not electrical remodeling or hypertrophy. Cardiovasc Res. 2010 Jan 6; 86(1):72-81.

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1.Bito V, deWaard MC, Biesmans L, Lenaerts I, Ozdemir S, Abdel-Mottaleb Y, Driesen R, Holemans P, Duncker DJ, Sipido K. Early exercise training after myocardial infarction prevents contractile but not electrical remodeling or hypertrophy. Cardiovasc Res. 2010 Jan 6; 86(1):72-81.

Yousra Mohamed Sabry Ahmed Abdelmottaleb

2010

1.Bito V, deWaard MC, Biesmans L, Lenaerts I, Ozdemir S, Abdel-Mottaleb Y, Driesen R, Holemans P, Duncker DJ, Sipido K. Early exercise training after myocardial infarction prevents contractile but not electrical remodeling or hypertrophy. Cardiovasc Res. 2010 Jan 6; 86(1):72-81.

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1. Diego-Garcia E, Schwartz E, Abdel-Mottaleb Y, Rodr?guez de la Vega R C, De Roodt A R, Tytgat J and. Possani LD. Scorpine and bKTX—like peptides from scorpion venoms: Genes, peptides and activities of the “orphan” components. The 16th International Society on Toxinology – European Section Meeting Leuven, Belgium, 7-10 September, 2008.

Yousra Mohamed Sabry Ahmed Abdelmottaleb

Leuven, Belgium

2008

Diego-Garcia E, Schwartz E, Abdel-Mottaleb Y, Rodr?guez de la Vega R C, De Roodt A R, Tytgat J and. Possani LD. Scorpine and bKTX—like peptides from scorpion venoms: Genes, peptides and activities of the “orphan” components. The 16th International Society on Toxinology – European Section Meeting Leuven, Belgium, 7-10 September, 2008.

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2. Vandendriessche T, Maertens C, Abdel-Mottaleb Y, Cuypers E, Nubbemeyer U, Mebs D, Tytgat J. PTX 251 D, a new modulator of voltage-gated ion channels: a joint venture alkaloid from arthropods and amphibians. 15th world congress on Animal, Plant and Microbial toxins: Glasgow 23-28 July 2006.

Yousra Mohamed Sabry Ahmed Abdelmottaleb

Glasgow UK

2006

2. Vandendriessche T, Maertens C, Abdel-Mottaleb Y, Cuypers E, Nubbemeyer U, Mebs D, Tytgat J. PTX 251 D, a new modulator of voltage-gated ion channels: a joint venture alkaloid from arthropods and amphibians. 15th world congress on Animal, Plant and Microbial toxins: Glasgow 23-28 July 2006.

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3. Abdel-Mottaleb Y, Kumar P, Ceard B, Bougie P, Martin-Eauclaire MF, Tytgat J. Evidence for a novel epitope for hERG channels blocking activity. 15th world congress on Animal, Plant and Microbial toxins: Glasgow 23-28 July 2006

Yousra Mohamed Sabry Ahmed Abdelmottaleb

Glasgow UK

2006

3. Abdel-Mottaleb Y, Kumar P, Ceard B, Bougie P, Martin-Eauclaire MF, Tytgat J. Evidence for a novel epitope for hERG channels blocking activity. 15th world congress on Animal, Plant and Microbial toxins: Glasgow 23-28 July 2006

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