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Staff Researches

Seham Elkheshen

Formulation Of Ciprofloxacin Hydrochloride Loaded Biodegradable Nanoparticles: Optimization Of Technique And Process Variables

Seham Abdel Khalek Abdel Wahab Elkheshen

Pharmaceutical Development And Technology, DOI: 10.3109/10837450.2013.836293 (2013) 1-10

2013

Poly lactic-co-glycolic acid (PLGA 502 H) nanoparticles incorporating ciprofloxacin HCI (CP) were prepared by double emulsion solvent diffusion technique. Methods: The influence of the application of probe sonication besides the high pressure homogenization in the preparation of the secondary emulsion and its application during the solidification step were studied. Their effect of the addition of polyvinyl alcohol (PVA) during the preparation of the primary emulsion was studied. Moreover, the effect of the addition of 0.1 M sodium chloride and/or adjusting the external and extracting phases of pH 7.4 were investigated. The selected formula was examined using IR, X-ray, DSC and SEM and in vitro drug release. Results: These formulations showed an appropriate particle size ranges between 135.7 – 187.85 nm, a mean zeta potential ranging from 0.839 to 6.81 mV and a mean of EE% which ranged from 35% to 69% Conclusion: The presented data revealed the superiority of using probe sonication besides high pressure homogenization during the formation of secondary emulsion. Moreover, the results indicated that the tested factors had a pronounced significant effect on the EE%.

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Formulation of Ciprofloxacin Hydrochloride Loaded Biodegradable Nanoparticles: Optimization of the Formulation Variables

Seham Abdel Khalek Abdel Wahab Elkheshen

Journal of Pharmaceutical Research and Opinion,3:11(2013) 72-81

2013

The aim of this work was to formulate nanoparticles with longer sustainment since it can play an important role in treatment of chronic osteomyelitis. A factorial design 2 was used to optimize the formulation variables of ciprofloxacin hydrochloride (CP) loaded biodegradable nanoparticles (NPS). The effect of three independent variables, namely: the polymer type (Poly D, L-lactide-co-glycolide 50/50 & Poly (D, L-lactide), the polymer molecular weight (M.Wt) and the drug to polymer ratio on the particle size, encapsulation efficiency (EE%), zeta potential and the time required for 90% of ciprofloxacin to be released (t90%) was investigated. The selected drug loaded nanoparticles was subjected to further investigations including: scanning electron microscope (SEM), DSC, x-ray powder diffractometry and FTIR spectroscopy. Moreover the antimicrobial effectiveness of the selected formula was investigated. The results revealed that the mean particle size ranged from 180-355 nm while the EE% ranged from 52-70%. The selected formula retained its antimicrobial activity throughout the preparation process.

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Formulation of Ciprofloxacin Hydrochloride Loaded Biodegradable Nanopparticles : Optimization of The Technique and Process Variables

Seham Abdel Khalek Abdel Wahab Elkheshen

The 3rd International Scientific Conference of Faculty of Pharmacy, Cairo University, 25-26 April 2012, Abstract book: PT-11, P: 55

2012

none

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Corticosteroid-loaded lipid nanocarriers as topical delivery system

Seham Abdel Khalek Abdel Wahab Elkheshen

The 3rd International Scientific Conference of Faculty of Pharmacy, Cairo University, 25-26 April 2012, Abstract book: PT-6, P: 50, In press

2012

none

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The 3rd International Scientific Conference of Faculty of Pharmacy

Seham Abdel Khalek Abdel Wahab Elkheshen

Cairo University Conference Center

2012

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FIP Pharmaceutical Sciences world congress in association with AAPS Annual Meeting

Seham Abdel Khalek Abdel Wahab Elkheshen

new Orleans, Louisiana, USA,

2010

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Formulation of Cefuroxime Oleogel for Intramammary Treatment of Mastitic Cows during the Non-Lactating Period

Seham Abdel Khalek Abdel Wahab Elkheshen

FIP Pharmaceutical Sciences world congress in association with AAPS Annual Meeting, new Orleans, Louisiana, USA, 14-18 November 2010.

2010

none

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Inclusion complexes of tadalafil with natural and chemically modified beta cyclodextrins - I: Preparation and in-vitro evaluation,

Seham Abdel Khalek Abdel Wahab Elkheshen

Europian Jurnal of Pharmaceutics and Biopharmaceutics 70, 819-827, 2008.

2008

none

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XXXI Conference of Pharmaceutical Sciences

Seham Abdel Khalek Abdel Wahab Elkheshen

Cairo, Egypt

2008

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In vitro and In vivo Evaluation of Controlled Release Buccoadhesive Desks of Timolol Maleate

Seham Abdel Khalek Abdel Wahab Elkheshen

J. Biomed. Sci., 23, 196-217, 2007.

2007

none

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