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Staff Researches

Marwa Shabayek

Non Classical Antifolates, Part 5. Benzodiazepine Analogs as a New Class of DHFR Inhibitors: Synthesis, Antitumor Testing and Molecular Modeling Study

Marwa Ismail Abdel latif Abou Shabayek

European Journal of Medicinal Chemistry 74 2014

2014

A new series of tetrahydro quinazoline and tetrahydro 1H dibenzo diazepine analogs were synthesized and tested for their DHFR inhibition and in vitro antitumor activity. Compound 35 showed a remarkable DHFR inhibitory potency which is twenty fold more active than methotrexate (MTX). Compounds 17 and 23 proved to be fifteen fold more active than the known antitumor 5 FU, with MG MID GI50, TGI and LC50 values of 1.5, 46.8, 93.3 and 1.4, 17.4, 93.3 respectively. Computer modeling studies allowed the identification that methoxy and methyl substituents, the system of the chalcone core, the nitrogen atoms, on the dibenzodiazepine ring as pharmacophoric features essential for activity. These mark points could be used as template model for further future optimization.

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Calcium homeostasis in progression of diabetic nephropathy

Marwa Ismail Abdel latif Abou Shabayek

2012

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- International Conference on Pharmaceutical Technology, Future University (2011).

Marwa Ismail Abdel latif Abou Shabayek

future university

2011

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Diagnostic evaluation of apoptosis inhibitory gene and tissue inhibitor matrix metalloproteinase-2 in patients with bladder cancer

Marwa Ismail Abdel latif Abou Shabayek

2010

Diagnostic evaluation of apoptosis inhibitory gene and tissue inhibitor matrix metalloproteinase-2 in patients with bladder cancer ; Sanaa Eissa, Marwa I. Shabayek, Manal F. Ismail, Raouf M. El-Allawy, and Mohamed A. Hamdy ;IUBMB Life ;62 (2), 394-399

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Seventh Scientific Conference in Quality Control of Drugs, Vaccines and Natural Products, NODCAR (2004).

Marwa Ismail Abdel latif Abou Shabayek

cairo

2004

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WHO Workshop on GMP and Inspection in collaboration with EMRO (2001).

Marwa Ismail Abdel latif Abou Shabayek

cairo

2001

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Customer Relationship Training Program, Biomedical Division, BAHGAT GROUP CO.

Marwa Ismail Abdel latif Abou Shabayek

cairo

2000

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