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Amr Mohamed Badawy

Basic information

Name : Amr Mohamed Badawy
Title: Professor of Analytical Chemistry
Google Schoolar Link: http://scholar.google.com.eg/citations?hl=en&user=Am8FhZcAAAAJ&view_op=list_works
Personal Info: Professor Amr Badawy, Professor of Analytical Chemistry - Department of Pharmaceutical Chemistry. He has a Ph.D and a MSC degree in Analytical Chemistry from Cairo university. View More...

Education

Certificate Major University Year
PhD Analytical Chemistry Faculty of Pharmacy, Cairo University 2003
Masters Analytical Chemistry Faculty of Pharmacy, Cairo University 1996
Bachelor Analytical Chemistry Faculty of Pharmacy, Cairo University 1991

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmacy, Cairo University Assistant Professor 01/01/2008 01/01/2013
Faculty of Pharmacy, Cairo University Lecturer 01/01/2003 01/01/2008
Faculty of Pharmacy, Cairo University Assistant Lecturer 01/01/1996 01/01/2003
Faculty of Pharmacy, Cairo University Demonstrator 01/01/1991 01/01/1996

Researches /Publications

Selective determination of tolterodine tartrate in presence of its oxidative - 01/1

Amr Mohamed Mohamed Badawy

Mamdouh R.Rezk1*,AmrM.Badawy1,2, OsamaAbdel Sattar3, OmaimaM.Khattab4

01/10/2016

Four stability-indicating methods were developed for determination of tolterodine tartrate in the presence of its oxidative degradation product (the metabolite). The degradation product was prepared via oxidation with hydrogen peroxide. The degradation product was characterized and structurally elucidated. The first method was the first derivative 1D by measuring the peak amplitude at 292nm. The second method was a second derivative by measuring the peak amplitude at 236, 287, 296 nm. The third method was a high performance liquid chromatographic using a reversed phase column and a mobile phase of phosphate buffer: methanol: triethyl amine (60: 40; 0.2 by volume). The forth method was a thin layer chromatography coupled with densitometric detection. Selective quantification of tolterodine in pure form, pharmaceutical formulation and/or in the presence of its degradant was demonstrated. The indication of stability was done under condition likely to be expected at normal storage condition.

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Determination of sparfloxacin and besifloxacin hydrochlorides using gold nanoparticles modified carbon paste electrode in micelliar medium - 01/0

Amr Mohamed Mohamed Badawy

Ali K. Attia,*a Amr M. Badawyb and Samr G. Abd-Elhamida

01/06/2016

A gold nanoparticles modified carbon paste electrode (AuCPE) was used to study the electrochemical behavior of sparfloxacin HCl (SPAR) and besifloxacin HCl (BESI) using cyclic and differential pulse voltammetry modes in the presence of micellar medium. Effect of different surfactants on peak current was studied in Britton–Robinson buffer solution of pH 2. Sodium dodecyl sulphate is the optimum surfactant based on the enhancement of the peak current. The modified electrode shows highly sensitive sensing giving an excellent response for SPAR and BESI. The peak current varied linearly over the concentration ranges from 1.1  107 mol L1 to 3.3  106 mol L1 and from 2.2  106 mol L1 to 5.5  105 mol L1 with determination coefficients of 0.9976 and 0.9984 in case of SPAR and BESI, respectively. The recoveries and the relative standard deviations were found in the following ranges: 99.97–101.4% and 0.63–1.48% for SPAR and 99.89–101.1% and 0.85–1.76% for BESI. The detections limits were 2.87  108 and 3.76  107 mol L1 for SPAR and BESI, respectively. The proposed method has been successfully applied to determine SPAR and BESI in biological fluids.

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Spectrophotometric and Spectrodensitometric Determination of Sparfloxacin and Besifloxacin Hydrochlorides in Presence of Their Peroxide Degradation Products - 01/1

Amr Mohamed Mohamed Badawy

Amr M. Badawy,Ali K. Attia,Abd-Elaziz E. Abd-Elaleem,Mona M.Abd-Elmoety,Samr G. Abd-Elhamid

01/10/2015

Three sensitive, selective and precise stability indicating methods were developed and validated for the determination of sparafloxacin hydrochloride (SPAR) and besifloxacin hydrochloride (BESI) in presence of their peroxide degradation products in bulk and pharmaceutical formulations. The first method, SPAR and BESI were determined using the first derivative (D1) spectrophotometric method by measuring the peak amplitudes at 283.5 nm and 258.6 nm for SPAR and BESI, respectively. Linear relationships were obtained in the ranges of 1.25-50 μg/mL and 2.5-80 μg/mL with mean recovery values of 99.79 ± 0.776 and 100.6 ± 0.550 for SPAR and BESI, respectively. The second method, the first derivative of the ratio spectra (DD1) was used to determine SPAR and BESI by measuring the peak amplitude at 390.8 nm and 353 nm for SPAR and BESI, respectively, over the same concentration range used in the first method with mean recovery values of 99.95 ± 0.992 and 99.91 ± 0.986 for SPAR and BESI, respectively. The third method, SPAR and BESI were determined using TLC-densitometric methods through the separation on silica gel plates using methanol: chloroform: ammonia (8.5:1:0.5 v:v:v) and methanol: chloroform: ammonia: toluene: water (8:2:2:2:2 v:v:v:v:v) for SPAR and BESI, respectively. These were followed by quantitative densitometric measurement at 290 nm and 275 nm for SPAR and BESI, respectively. Linear relationship were obtained in the concentration ranges of 0.5-8 μg/spot and 1-10 μg/spot with mean recovery values of 100.1 ± 0.772 and 100.2± 0.981 for SPAR and BESI, respectively. The proposed methods have been successfully applied to the analysis of SPAR and BESI in their pharmaceutical formulations without interference from other additives and the results were statistically compared with official methods.

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Spectrophotometric and Spectrodensitometric Determination of Sparfloxacin and Besifloxacin Hydrochlorides in Presence of Their Peroxide Degradation Products - 01/1

Amr Mohamed Mohamed Badawy

Amr M. Badawy,Ali K. Attia,Abd-Elaziz E. Abd-Elaleem,Mona M.Abd-Elmoety,Samr G. Abd-Elhamid

01/10/2015

Three sensitive, selective and precise stability indicating methods were developed and validated for the determination of sparafloxacin hydrochloride (SPAR) and besifloxacin hydrochloride (BESI) in presence of their peroxide degradation products in bulk and pharmaceutical formulations. The first method, SPAR and BESI were determined using the first derivative (D1) spectrophotometric method by measuring the peak amplitudes at 283.5 nm and 258.6 nm for SPAR and BESI, respectively. Linear relationships were obtained in the ranges of 1.25-50 mg/mL and 2.5-80 mg/mL with mean recovery values of 99.79 ± 0.776 and 100.6 ± 0.550 for SPAR and BESI, respectively. The second method, the first derivative of the ratio spectra (DD1) was used to determine SPAR and BESI by measuring the peak amplitude at 390.8 nm and 353 nm for SPAR and BESI, respectively, over the same concentration range used in the first method with mean recovery values of 99.95 ± 0.992 and 99.91 ± 0.986 for SPAR and BESI, respectively. The third method, SPAR and BESI were determined using TLC-densitometric methods through the separation on silica gel plates using methanol: chloroform: ammonia (8.5:1:0.5 v:v:v) and methanol: chloroform: ammonia: toluene: water (8:2:2:2:2 v:v:v:v:v) for SPAR and BESI, respectively. These were followed by quantitative densitometric measurement at 290 nm and 275 nm for SPAR and BESI, respectively. Linear relationship were obtained in the concentration ranges of 0.5-8 μg/spot and 1-10 μg/spot with mean recovery values of 100.1 ± 0.772 and 100.2± 0.981 for SPAR and BESI, respectively. The proposed methods have been successfully applied to the analysis of SPAR and BESI in their pharmaceutical formulations without interference from other additives and the results were statistically compared with official methods Spectrophotometric and Spectrodensitometric Determination of Sparfloxacin and Besifloxacin Hydrochlorides in Presence of Their Peroxide Degradation Products (PDF Download Available). Available from: https://www.researchgate.net/publication/283420761_Spectrophotometric_and_Spectrodensitometric_Determination_of_Sparfloxacin_and_Besifloxacin_Hydrochlorides_in_Presence_of_Their_Peroxide_Degradation_Products [accessed Dec 20, 2015].

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Stability-Indicating Methods for the Determination of Gemifloxacin in Presence of Its Acid Degradation Product - 01/1

Amr Mohamed Mohamed Badawy

Ezzat M. Abdel-Moety, Amr M. Badawey, Hebatallah M. Essam and Fatma M. Aboul Alamine

01/10/2015

Brilliant, valid and simple five UV spectrophotometric stability indicating techniques are adopted for the determination of Gemifloxacin (GEM) in presence of its acid degradation products over a concentration range of 2-12 μg mL-1. The first method is an application of the first derivative (1D) spectrophotometry, that allows the determination of GEM without interference of its acid degradation products at zero crossing wavelength (254.6 nm). The second method depends on the first-derivative of the ratio spectra spectrophotometry (1DD) for determination of GEM in presence of its acid degradation products at a maximum of 273.0 nm and a minimum of 284.0 nm, While the third dual wavelength method offers a superior stability indicating procedures for the determination of GEM in the zero order spectra at the wavelength pair of 271.8 nm and 325.0 nm. The fourth method is the ratio difference one, with the advantages of minimal data processing and wide range of application. It is applied for the analysis of intact drug in presence of its acid degradation products by measuring the difference in the peak amplitude at the ratio spectra at 355.0 nm and 270.0 nm. The last method is based on the quantification of GEM through the bivariate calibration at 255.0 nm and 277.0 nm by adopting simple mathematic algorithm that provides simplicity and rapidity.

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