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Heidi Mohamed Abdel Mageed

Basic information

Name : Heidi Mohamed Abdel Mageed
Title: Lecturer
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Personal Info: Dr. Heidi Mohamed, lecturer of Pharmaceutical Technology, Pharmaceutics and Pharmaceutical Technology Department. she got her Master degree from Cairo university 2005 and PhD from GUC 2010. View More...

Education

Certificate Major University Year
PhD 2013
PhD Pharmaceutical Technology German University in Cairo (GUC) 2010
Masters 2006
Masters Pharmaceutics Cairo University 2005
Bachelor of Science Pharmacy Cairo University 2001
Bachelor of Science 2001

Teaching Experience

Name of Organization Position From Date To Date
GUC (German University in Cairo) Post doctoral fellowship 01/01/2006 01/01/2014

Researches /Publications

Electron Spin Resonance Study on Sugar Ester Nano Vesicles Entrapping Active catalase - 01/0

Heidi Mohamed Abdel Mageed Abdel Aziz

01/02/2016

Therapeutic application of enzymes demands the presence of a stable enzyme formulation. In this study, catalase enzyme (CAT) was entrapped in biocompatible biodegradable flexible sugar esters (SE) nano vesicles to improve the stability of its tetrameric structure and antioxidant activity. Thin film hydration method was used for enzyme entrapment in SE vesicles, where the formulation conditions used proved to preserve the fragile nature of the enzyme. In addition, electron spin resonance (ESR) was used to test the general hypothesis that vesicles composition, including lecithin and cholesterol influence the fluidity of vesicles bilayer and hence its flexibility. For this purpose the effect of phospholipids of different composition and the influence of different concentrations of cholesterol on vesicles bilayer fluidity was studied using ESR. Owing to the nondestructive nature of ESR measurements it is considered a well suited technique to monitor as well the encapsulated CAT inside vesicles without affecting its activity. Two different nitroxide spin probes were used, that is 16-doxyl stearic acid (16-DSA) for the study of the different dynamic properties of vesicles bilayer and 3-(2-iodoacetamido) proxyl (IAA) for ESR measurements of entrapped CAT in SE vesicles. The results obtained indicated the coexistence of two regions in the bilayer of the tested vesicles, one richer in cholesterol (and more rigid) and one with less cholesterol content (and more mobile). It was also concluded that CAT is not freely moving inside the vesicle rather its movement became restricted upon encapsulation inside the vesicle. This could account for the high stability observed for entrapped CAT compared to the free one. The flexible CAT nano SE vesicles developed in this study are considered to be a novel addition to Pharmaceutical industry arsenal for a safe active CAT topical application.

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Development of novel flexible sugar ester vesicles as carrier systems for the antioxidant enzyme catalase for wound healing applications - 01/0

Heidi Mohamed Abdel Mageed Abdel Aziz

01/04/2012

The antioxidant enzyme catalase (CAT) was encapsulated in biocompatible flexible non-ionic sugar esters (SEs)nano-vesicles forpotentialtopical administration. The effects ofthe SEhydrophilic lipophilic balance (HLB) value and the carbon chain length of the fatty acid ester of different SEs on the encapsulation efficiency (EE) were studied. Morphology of the vesicles was not altered upon CAT encapsulation using freeze fracture electron microscopy. The extrusion measurements indicated that there was an increase in the vesicle’s flexibility index upon the inclusion of phospholipids. The mean diameter of the CAT-EV (ester vesicle; HSC and HSC–PL) was 222–275 nm using laser diffraction measurements. The catalytic efficiency (Vmax/Km) of CAT was improved after encapsulation by a factor of 1.7. Both free CAT and CATEV showed maximum catalytic activity at pH 7.0, and CAT-EV was more stable than free CAT at acidic pH, which is advantageous for successful topical delivery. Encapsulation of CAT in SE vesicles protected it against trypsin treatment. Encapsulated CAT retained more than 60% residual activity after 12 successive decomposition cycles of H2O2. CAT-EV activity was significantly preserved compared to that of free CAT at 4 ◦C for 180 days. The in vivo study showed a significant effect of the prepared CAT nano-vesicles on wound healing.

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Competitive Research Proposal Writing training module -

Heidi Mohamed Abdel Mageed Abdel Aziz

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Awards

Award Donor Date
Prize of distingushed scientific publication King Abdel Aziz university KSA 2013
Prize of distingushed scientific publication King Abdel Aziz university KSA 2012

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