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Nasser Saad

Basic information

Name : Nasser Saad
Title: Associate Professor of Pharmaceutical Chemistry
Google Schoolar Link: http://scholar.google.com.eg/citations?hl=en&user=Ja7kt4oAAAAJ&view_op=list_works
Personal Info: Dr. Nasser Saad Mohamed Ismail, Ass. prof of Pharmaceutical Chemistry - Department of Pharmaceutical Chemistry. He has a PH.D and MSC degree from Ain Shams university. He received PH.D from Ain Sham University, March 2006 and Associate Professor of Pharmaceutical Chemistry April 2011. View More...

Education

Certificate Major University Year
PhD Pharmaceutical Chemistry Ain Shams University 2006
Masters Pharmaceutical Chemistry Ain Shams University - Pharmaceutical Chemistry 2001
Bachelor Pharmaceutical Sciences Zagazig University _ Faculty of Pharmaceuitical Scince 1996

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmacy, Future University associate professor of Pharmaceutical Chemistry 01/01/2014 01/01/2016
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University Lecturer 01/03/2006 01/04/2011
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University Assistant Lecturer 01/03/2001 01/02/2006
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University. Demonstrator 01/11/1996 01/02/2001

Researches /Publications

Rational design, synthesis and 2D-QSAR studies of antiproliferative tropane-based compounds† - 01/1

Nasser Saad Mohamed Ismail

Riham F. George, Rabah A. T. Serya, Fady N. Baselious, May El-Manawaty, ElSayed M. Shalaby and Adel S. Girgis

01/10/2016

3,4-Diaryl-11-methyl-7-[(aryl)methylidene]-4,5,11-triazatricyclo[6.2.1.0*2,6*]undec-5-enes 14a–s were synthesized through reaction of 2,4-bis[(aryl)methylidene]-8-methyl-8-azabicyclo[3.2.1]octan-3-ones 12a–f with aryl hydrazines in the presence of catalytic amount of thiamine hydrochloride. Meanwhile, the 4-acetyl analogs 16a,b were obtained through reaction of 12b,e and hydrazine hydrate in acetic acid. Good support for the structure was received from single crystal X-ray studies of 14a. Some of the synthesized tropane containing-compounds showed promising antitumor properties during the in vitro MTT bio-assay against HepG2 (hepatocellular) and MCF7 (breast) human tumor carcinoma cell lines, with potency higher than that of doxorubicin (DNA intercalating agent, standard reference). Statistically significant 2D-QSAR model describes the antitumor properties against MCF7.

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Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents - 01/0

Nasser Saad Mohamed Ismail

Ghada M.E. Ali, Diaa A. Ibrahim, Amira M. Elmetwali

01/08/2016

Pyrazolo pyrimidines are fused heterocyclic ring systems which known as bioisosteres of adenine, that are necessary for every aspect of cell life. Pyrazolo[1,5- a]pyrimidines derivatives have been explored for their inhibitory activity towards a variety of protein kinase enzymes and their function as anticancer agents. This review to the best of our knowledge is the first assemblage on synthesis and medicinal aspects including structure activity relationships of pyrazolo[1,5-a]pyrimidines reported to date.

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Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity - 01/0

Nasser Saad Mohamed Ismail

Aliya M. S. El Newahie, Dalal A. Abou El Ella, and Khaled A. M. Abouzid

01/03/2016

Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure–activity relationship studies reported to date.

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Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents - 01/0

Nasser Saad Mohamed Ismail

Eslam M.H. Ali d, 1, Diaa A. Ibrahim c, Rabah A.T. Serya, Dalal A. Abou El Ella

01/03/2016

Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidines derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents. The present review to the best of our knowledge is the first compilation on synthesis and medicinal aspects including structureeactivity relationships of pyrazolo[3,4-d]pyrimidines reported to date.

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Recent advances in 4-aminoquinazoline based scaffold derivatives targeting EGFR kinases as anticancer agents - 01/0

Nasser Saad Mohamed Ismail

Rania S.M. Ismail, Sahar Abuserii d, Dalal A. Abou El Ella c

01/03/2016

Quinazoline derivatives are fused heterocyclic ring systems which have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents. The present review to represent the most recent synthetic strategies and medicinal aspects including structure activity relationships of substituted quinazolines as EGFR inhibitors reported to date.

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