Future University is one of most promising private universities in Egypt. Through excellence in teaching, research and service, Future University strives to provide a comprehensive, high-quality education that prepares our graduates to be future leaders.
90th Street
New Cairo

Staff Researches

Salwa Abdelwahhab

Formulation Of Ciprofloxacin Hydrochloride Loaded Biodegradable Nanoparticles: Optimization Of Technique And Process Variables

Salwa Saleh Abdelwahhab El Sayed

Pharmaceutical Development And Technology


Poly lactic-co-glycolic acid (PLGA 502 H) nanoparticles incorporating ciprofloxacin HCI (CP) were prepared by double emulsion solvent diffusion technique. Methods: The influence of the application of probe sonication besides the high pressure homogenization in the preparation of the secondary emulsion and its application during the solidification step were studied. Their effect of the addition of polyvinyl alcohol (PVA) during the preparation of the primary emulsion was studied. Moreover, the effect of the addition of 0.1 M sodium chloride and/or adjusting the external and extracting phases of pH 7.4 were investigated. The selected formula was examined using IR, X-ray, DSC and SEM and in vitro drug release. Results: These formulations showed an appropriate particle size ranges between 135.7 – 187.85 nm, a mean zeta potential ranging from 0.839 to 6.81 mV and a mean of EE% which ranged from 35% to 69% Conclusion: The presented data revealed the superiority of using probe sonication besides high pressure homogenization during the formation of secondary emulsion. Moreover, the results indicated that the tested factors had a pronounced significant effect on the EE%.

Download PDF
Synthesis of novel 2,3- disubstituted quinazoline- 4(3H) ones and their effect on the ultrastructure of some pathogenic microorganisms

Salwa Saleh Abdelwahhab El Sayed



A series of highly functionalized hitherto unreported quinazolinones with different substituent at position 3 have been concisely synthesized in good yields via the reaction of 3-amino-6-bromo-2-undecylquinazoline-4(H)one with one carbon donor such as phenylisothiocyanate, α- halogenated compounds and chloroacetylchloride. Moreover, the reaction of 6-bromo-2-undecylbenzoxazin-4(H)onewith different hydrazides and 2-aminothiophenol was also investigated.The structures of all new synthesized compounds in this investigation were determined using spectroscopic tools (IR, 'HNMR, MS and 13C-NMR).

Download PDF

Follow us on

Visit the Faculty