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Staff Researches

Iten Mamdouh Fawzy

“Design and synthesis and biological evaluation of novel curcumin analogs with anticipated anticancer activity”Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, J.Gulbo, Khaled A.M. Abouzid

Iten Mamdouh Fawzy Abd El Moteleb

Khairia M. Youssef, Nasser S.M. Ismail, J. Gullbo, Khaled A.M. Abouzid

Future Journal of Pharmaceutical Sciences

2015

Extensive research conducted within past years revealed that curcumin is a highly pleiotropic molecule that interacts with a diverse range of molecular targets and hence it possess anti-proliferative activities against tumor cells.The great similarities between curcumin analogs and chalcones inspired their testing against tubulin enzyme activity as recent research revealed that chalcones possess cytotoxic activity associated with tubulin inhibition and interference with microtubule formation, which is essential in mitosis and cell replication.

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Newly Designed and Synthesized Curcumin Analogs with in vitro Cytotoxicity and Tubulin Polymerization Activity Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, J.Gulbo, Khaled A.M. Abouzid

Iten Mamdouh Fawzy Abd El Moteleb

Journal of Chemical Biology and drug design

2014

Novel curcumin analogs with 4-piperidone ring were designed, synthesized, and evaluated for their cytotoxic activities against five different cancer cell lines. 3,5-bis(4-Hydroxy-3-methoxybenzylidene)-4-oxo-N-phenylpiperidine-1-carbothioamide (XIIe) exhibited considerable cytotoxic activity with IC50 values in 1–2.5 μm range. In silico and in vitro, studies were also performed to predict the binding affinity of the target compounds to the β-chain of tubulin receptor (PDB code 1SA1) and their abilities to affect microtubules polymerization cycle. 3,5-bis(3-Iodo-5-methoxy-4-propoxybenzylidene)-N-acetylpiperidin-4-one (VIIa) was found to exert 93.3% inhibition of tubulin and destabilization of microtubules in vitro compared to vincristine while, 3,5-bis(3,4,5-trimethoxybenzylidene)-N-benzoylpiperidin-4-one (XIIc) showed high potency in a different way where it exerted 94.8% stabilization of microtubules in vitro compared to positive control paclitaxel.

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Novel Curcumin Analogs Modeling, Synthesis, Tubulin polymerization and Cytotoxic assays.Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, J.Gulbo, Khaled A.M. Abouzid

Iten Mamdouh Fawzy Abd El Moteleb

Annual International Conference on Pharmaceutical Sciences,

2014

Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione] is the major constituent of turmeric powder extracted from the rhizome of the plant curcuma longa. Extensive research conducted within the past years has revealed that curcumin is a highly pleiotropic molecule that modulates and interacts with a diverse range of molecular targets and hence it possess anti-proliferative activities against tumor cells in vitro, anti-inflammatory, antibacterial, antiviral, anti-hepatotoxic, hypotensive and anti-cholesterolemic activities. Since cancer is a result of the dys-regulation of multiple cell signaling pathways so curcumin’s multi-targeting ability may be the key to its therapeutic potential against cancer. Also the great similarity in structure between curcumin analogs and chalcones inspired their testing against tubulin enzyme activity. Recent research revealed that chalcones possess cytotoxic activity associated with tubulin inhibition and interference with microtubule formation, which is essential in cellular processes such as mitosis and cell replication

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Novel Curcumin Analogs Modeling, Synthesis, Tubulin polymerization and Cytotoxic assays.

Iten Mamdouh Fawzy Abd El Moteleb

2014

Athens Institute for Education and Research Annual International Conference on Pharmaceutical Sciences, Athens, Greece

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Molecular docking and in silico ADME study of Novel N9-substituted Purines targeting CK1 and abl-tyrosine kinase

Iten Mamdouh Fawzy Abd El Moteleb

2014

FIP Bangkok

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Newly designed and synthesized curcumin analogs with in vitro cytotoxicity and tubulin polymerization activity

Iten Mamdouh Fawzy Abd El Moteleb

2014

Journal of Chemical Biology and Drug Design

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Molecular docking and in silico ADME study of Novel N9-substituted Purines targeting CK1 Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, Dina M. Lasheen, Khaled A.M. Abouzid

Iten Mamdouh Fawzy Abd El Moteleb

FIP, Bangkok, Thailand

2014

Molecular docking and in silico ADME study of Novel N9-substituted Purines targeting CK1 and abl-tyrosine kinase

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“Design and synthesis and biological evaluation of novel curcumin analogs with anticipated anticancer activity”

Iten Mamdouh Fawzy Abd El Moteleb

2013

Synthesis of new anticancer drugs and their biological evaluation

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“Modeling and synthesis of novel curcumin analogs with anticipated anticancer activity”

Iten Mamdouh Fawzy Abd El Moteleb

2013

sybthesis and molecular modeling study of new anticancer drugs together with their biological evaluation

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Design and synthesis of curcumin analogs with anticipated anticancer activityIten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, Khaled A.M. Abouzid

Iten Mamdouh Fawzy Abd El Moteleb

Ain shams University,Future university in egypt, University of Alexandria

2013

master thesis

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FUE international conference of pharmaceutical studies

Iten Mamdouh Fawzy Abd El Moteleb

conferences hall

2013

one of the organization members of the conference and a member of the drug design and discovery workshop

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“Modeling and synthesis of novel curcumin analogs with anticipated anticancer activity”Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, J.Gulbo, Khaled A.M. Abouzid

Iten Mamdouh Fawzy Abd El Moteleb

FIP, Dublin-Ireland

2013

Molecular Modeling and biology assays for curcumin analogs

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