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khairia M. Youssef

Basic information

Name : khairia M. Youssef
Title: Professor of Pharmaceutical Organic Chemistry
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Personal Info: Professor Khairia Youssef, Professor of Organic Chemistry, Department od Pharmaceutical Chemistry. • Dr. Khairia had the Bachelor of Pharmaceutical Sciences, the Master degree and Ph.D. in Organic Chemistry from Faculty of Pharmacy, Cairo University on 1977, 1980 and 1984, respectively. • On 1988, Dr. Khairia was on a special research assignment with Etreby Computer in Los Angeles, California, U.S.A. • On 1992, Dr. Khairia was on a Peace Fellowship for Post Doctoral Research which concerns with "Design and Synthesis of Potential Antileukemic and/or Antiviral 2'-Deoxymethylene Nucleosides" at the University of Southern California, Los Angeles, California. U.S.A., under the supervision of Dr. Eric J. Lien, Ph. D. The design of the work is based on QSAR. • Prof. Dr. Youssef is interested in drug design, synthesis and evaluation of certain pharmacologically active compounds. Prof. Youssef had been awarded the Bronze award from King Abdul Aziz city for science and technology for the exclusive research “Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents” which had been granted by King Abdul Aziz city for science and technology, Project No. AR 19-39. Prof. Youssef had been awarded a certificate from The Marquis Who's who Publications Board as a subject of biographical record in Who's who in Science and Engineering 2008-2009. Inclusion in which is limited to those individuals who have demonstrated outstanding achievement in their own fields of endeavor and who have, thereby, contributed significantly to the betterment of contemporary society. She had been awarded the silver award from King Abdul Aziz city for science and technology for the exclusive research “Novel Modified Estrogens: Synthesis, Binding Affinity to Estrogen Receptor, Biological and Antitumor Activities of various Novel Modified Estrogen” which had been granted by King Abdul Aziz city for science and technology, Project No. AR 24-4. Prof. Youssef had been awarded the FUE Azazi Award for Outstanding Research for the academic year 2012/2013. This reflects well on the important contributions to the scholarly reputation of FUE. Perzigian, Anthony (perzigaj) [email protected] Prof. Youssef as an International Conference Organizer had been awarded a Certificate for Participating as Organizer for the 1st FUE International Conference on Pharmaceutical Technologies (1st FUE-ICPT), Feb, 2012.http://icpt.fue.edu.eg/ Also, Prof. Youssef had been awarded a Certificate for Participating as Organizer for 3rd FUE International Conference of Pharmaceutical Sciences (3rd FUE-ICPS), Feb, 9-11, 2015. http://www.fue.edu.eg/pharmaconference. Finally, Prof. Youssef was informed that the organizing committee of OMICS International Pharma Middle East Conference November 02-04, 2014, Dubai, UAE are pleased to join them and give a keynote presentation on: Targeted Drug Delivery System (TDDS): Encapsulating Newly Synthesized Anti-cancer Compounds-Conjugated Gold Nanoparticles Also, she was informed that the selection committee has decided to be one of the Conference Organizing Committee. www.conferenceseries.com View More...

Education

Certificate Major University Year
PhD Organic Chemistry Faculty of Pharmacy - Cairo University 1984
Masters Organic Chemistry Cairo University - Faculty of Pharmacy 1980
Bachelor . Cairo University - Faculty of Pharmacy 1977

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt Professor of Pharmaceutical Organic Chemistry 01/01/2007 01/01/2016
Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt Professor of Pharmaceutical Organic Chemistry 01/01/2007 01/01/2015
Faculty of Pharmacy, King Saud University, K.S.A. Professor at the Pharmaceutical Chemistry Department 01/01/2005 01/01/2007
College of Pharmacy, Science and Medical studies Department, King Saud University, K.S.A. Head of Pharmaceutical Chemistry Department 01/01/2002 01/01/2005
Faculty of Pharmacy, King Saud University Professor at Pharmaceutical Chemistry Department 01/01/1999 01/01/2002
Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Saud University Associate Professor 01/01/1994 01/01/1999
Faculty of Pharmacy, Cairo University Assistant Professor at the Organic Chemistry Department 01/01/1992 01/01/1994
Faculty of Pharmacy, Cairo University Assistant Professor at the Organic Chemistry Department 01/01/1989 01/01/1991

Researches /Publications

67. Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agents. - 01/0

Khairia Mohamed Ahmed Youssef

Iten M Fawzy1, Khairia M Youssef1, Deena S Lasheen2, Nasser SM Ismail1 & Khaled AM Abouzid2

01/05/2018

Imatinib possesses various mechanisms for combating cancer, making the development of imatinib analogs an attractive target for cancer research. Method: Two series of analogs were designed and synthesized, maintaining the essential pharmacophoric features in imatinib structure. The synthesized compounds were subjected to cell-based antiproliferative assays against nonsmall lung (A549) and colon cancer cell lines. In addition, flow cytometry cell cycle and caspase-3 colorimetric assays were performed. Results: Most compounds showed potent anticancer activity against both cell lines with IC50 = 0.14–5.07 μM. Three compounds demonstrated ability to reinforce cell cycle arrest at G1 stage in a manner similar to imatinib. In addition, they induced apoptosis via activation of caspase-3.

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N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, - 01/1

Khairia Mohamed Ahmed Youssef

Iten M. Fawzy a, Hussein I. El-Subbagh

01/12/2017

Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described. Then, a series of hybrids have been developed by introducing Free radical scavengers. Molecular modeling was performed and structure activity relationships are discussed. Among the series, most potent compounds showed effective AchE inhibitions, high selectivity over butyrylcholinesterase and high radical scavenging activities. On the basis of this work, the ability of analogs containing nipecotic acid scaffold to serve in the design of Nbenzyl- piperidine linked multipotent molecules for the treatment of Alzheimer Disease.

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Medicinal Attributes of Thienopyrimidine Based Scaffold Targeting - 01/1

Khairia Mohamed Ahmed Youssef

Amna Ghith1, Nasser S.M. Ismail 1, Khaled A.M. Abouzid2

01/11/2017

Thienopyrimidines (TP), comprising a thiophene ring fused with pyrimidine, are famous bioisosteres to purines, an essential part of the human metabolome. This scaffold has become an interesting structural element in the development of pharmaceutical compounds, due to their wide spectrum applications as cytotoxic agents against different types of human cancer cell lines, cGMP phosphodiesterase inhibitors, and anti-viral, anti-inflammatory, and anti-microbial agents. The structural similarity of this scaffold with adenine made it an excellent moiety to be used in the design of kinase inhibitors. This review focuses on the chemistry of thienopyrimidine derivatives, their potential activities against various kinases, and their structure–activity relationship studies.

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Design and synthesis of potential Ribonucleotide reductase enzyme (RNR) inhibitors as antileukemic and/or antiviral 2'-Deoxymethylene Nucleosides - 01/0

Khairia Mohamed Ahmed Youssef

Eric J. Lien

01/08/2016

In order to improve the antitumor and/or antiviral activities of existing nucleoside analogs, eight new compounds (9a,b, 14a,b, 15a,b and 16a,b) were designed and synthesized. Halogen atom were incorporated at the 2-position of the purine base to render the amino group at the 6-position less susceptible to metabolism by adenosine deaminase. A methylene group was introduced at the 2'-position following the lead of nucleoside antibiotics angustmycin A and neplanocin A. The two key intermediates 9a and 9b were prepared from guanosine after protection of the 3' and 5' hydroxyl groups and oxidation of the 2' hydroxyl group to the corresponding carbonyl group using swern method. The conversion of the carbonyl group to the methylene function was carried out by applying wittig reaction conditions. The final compounds 14 a,b, 15 a,b, 16 a,b were prepared by means of nonaqueous diazotization of 9a and 9b. The prepared compounds were subjected to in vitro antileukemic and antiviral activity upon a new L1210 cell line that is doubly resistant to both hydroxyurea and deoxyadenosine which was grown and characterized. The new compounds showed potent antileukemic activity.

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Design and synthesis of potential Ribonucleotide reductase enzyme (RNR) inhibitors as antileukemic and/or antiviral 2'-Deoxymethylene Nucleosides - 01/1

Khairia Mohamed Ahmed Youssef

Prof. Dr. Eric J. Lien

01/12/2015

In order to improve the antitumor and/or antiviral activities of existing nucleoside analogs, eight new compounds (9a,b, 14a,b, 15a,b and 16a,b) were designed and synthesized. Halogen atom were incorporated at the 2-position of the purine base to render the amino group at the 6-position less susceptible to metabolism by adenosine deaminase. A methylene group was introduced at the 2'-position following the lead of nucleoside antibiotics angustmycin A and neplanocin A. The two key intermediates 9a and 9b were prepared from guanosine after protection of the 3' and 5' hydroxyl groups and oxidation of the 2' hydroxyl group to the corresponding carbonyl group using swern method. The conversion of the carbonyl group to the methylene function was carried out by applying wittig reaction conditions. The final compounds 14 a,b, 15 a,b, 16 a,b were prepared by means of nonaqueous diazotization of 9a and 9b. The prepared compounds were subjected to in vitro antileukemic and antiviral activity upon a new L1210 cell line that is doubly resistant to both hydroxyurea and deoxyadenosine which was grown and characterized. The new compounds showed potent antileukemic activity.

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Awards

Award Donor Date
AZAZI FUE Award for Outstanding Research Future University in Egypt 2013
the Bronze award from King Abdul Aziz city for science and technology for the exclusive research “Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents” which had been granted by King Abdul Aziz city for science and technology, Project No. AR 19-39. King Abdul Aziz city for science and technology 2010
D. Walid Bin Amin El-Kayaly For Scintific Research award- Saudy Pharmaceutical Syndicate, for the research titled: Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs. El-Kayaly For Scintific Research award- Saudy Pharmaceutical Syndicate, Saudi Arabia 2010
A certificate from The Marquis Who's who Publications Board as a subject of biographical record in Who's who in Science and Engineering 2008-2009. Who's who in Science and Engineering, USA 2009
the silver award from King Abdul Aziz city for science and technology for the exclusive research King Abdul Aziz city for science and technology, Saudi Arabia 2008

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