Future University In Egypt (FUE)
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Abdelfattah Ahmed Abdelkhalek Ahmed Soliman

Basic information

Name : Abdelfattah Ahmed Abdelkhalek Ahmed Soliman
Title: Lecturer
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Personal Info: Abdelfattah Ahmed, Lecturer at Department of Microbiology of Supplementary General Science, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt

Education

Certificate Major University Year
PhD Microbiology Alazhahr University-Faculty of Scinces 2014
ماجستير Microbiology Faculty of Scinces - Alazhahr University 2010
بكالوريوس علوم 2005

Teaching Experience

Name of Organization Position From Date To Date
general science department teaching 01/01/2016 01/01/2018

Researches /Publications

Derivatives of Cucurbitacin-E-Glucoside Produced by Curvularia lunata NRRL 2178: Anti-inflammatory, Antipyretic, Antitumor Activities, and Effect on Biochemical Parameters - 01/0

Abdelfattah Ahmed Abdelkhalek Ahmed Soliman

Abdelfattah A.AbdelkhalekaAbdel-Monem M.A.SharafbMohamedRabiecHussein I.El-Subbagh

01/04/2017

E glucoside (1) is a tetracyclic triterpenoid glucoside, isolated from Cucurbitaceae plants. In the present study the pharmacological and biochemical effects of cucurbitacin-E-glucoside and two of its microbial transformation derivatives (2 and 3) produced by Curvularia lunata NRRL 2178, were investigated. The isolated compounds were identified by 1H and 13C NMR spectroscopy. The obtained results showed that 2 and 3 possess anti-inflammatory and antipyretic effects, compared with indomethacin and acetaminophen. Oral administration of 2 and 3 at dose of 1/10 of LD50 for 30 days resulted in a significant decrease in the serum levels of glucose, cholesterol and triacylglycerol. Cucurbitacin–E-glucoside showed moderate cytotoxicity against tumor cell lines while compound 3 proved to be selective against colon carcinoma cell lines.

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