Principles and applications of biopharmaceutics including physico-chemical, physiological and formulation factors affecting drug bioavailability. Sustained release formulation and evaluation. Study of the kinetics of drug absorption, distribution, metabolism and elimination of the drug in the body. It includes compartmental models, volume of distribution, mathematical review, kinetics of pharmacological effect, multiple dosing, renal impairment, renal and hepatic excretions and dosage regimen adjustment.
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