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Dalia Samuel

Basic information

Name : Dalia Samuel
Title: Professor of Pharmaceutical Sciences
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Personal Info: Prof. Dr. Dalia Samuel, professor of Pharmaceutics at Pharmaceutics and Pharmaceutical Technology Department. her doctoral research was performed at the University of Utah, USA with (distinguished) Prof. William I. Higuchi on transdermal drug delivery. Her post doctorate research was conducted at Oregon State University, Corvallis, Oregon, USA, on transdermal vaccines. View More...


Certificate Major University Year
PhD Pharmaceutical Sciences Helwan University - Faculty of Pharmcy 2003
Masters Pharmaceutical Sciences Helwan University - Faculty of Pharmacy 2000
Bachelor Pharmaceutical Sciences Cairo University - Faculty of Pharmacy 1994

Teaching Experience

Name of Organization Position From Date To Date
FUE, Cairo, Egypt Professor of Pharmaceutics 01/01/2013 01/01/2016
Dept. of Pharmaceutics, Oregon State University, Corvallis, Oregon, USA Post doctorate candidate 01/01/2006 01/01/2007
Dept. of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA PhD student 01/01/2000 01/01/2002
Faculty of Pharmacy, Dept. of Pharmaceutics, Helwan University, Cairo, Egypt TA, Lecturer then Associate Professor of Pharmaceutics 01/01/1995 01/01/2013

Researches /Publications

Nanoemulsion: A review on mechanisms for transdermal delivery of hydrophobic and hydrophilic drugs. - 01/0

Dalia Samuel Shaker Kirolos

Dalia S. Shaker, Rania A. H. Ishak, Amira Ghoneim and Muaeid A Elhuoni.


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Optimization of nano spray drying parameters for production of α-amylase nanopowder for biotheraputic applications using factorial design - 01/0

Dalia Samuel Shaker Kirolos

Heidi M. Abdel-Mageed, Shahinaze A. Fouad, Mahmoud H. Teaima


This study was designed to optimize the effect of operating conditions and formulation parameters using various additives to develop a-amylase nanoparticles. a-Amylase was chosen due to its importance in the substantial number of industrial processing with emphasis on pharmaceutical industry. Factorial statistical design was adopted to effectively optimize the size, yield value, residual enzyme activity, and morphology of a-amylase nanoparticles using Nano Spray Dryer B€UCHI B-90. The physicochemical characterization of the prepared nanopowder was carried out using zetasizer and scanning electron microscopy (SEM) and enzyme activity assay. Results showed that the type of additive and mesh size significantly influenced the particles size and yield value. SEM images showed three different structure patterns where particle morphology was influenced by TweenVR 80 or sucrose at low concentration (0.05%). Optimized spherical nanoparticles (600nm) was obtained using 7 mm mesh cap size, sucrose (0.15%), 95% yield value, drying flow rate (100 L/min), and inlet temperature of 80 C. Higher storage stability was detected for enzyme spray-dried using larger cap size. It was concluded that nano spray drying of aqueous enzyme solution under determined operating conditions produced stable a-amylase powders. This would extend the application of the enzyme in a variety of pharmaceutical products.

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Butoconazole nitrate vaginal sponge: Drug release and antifungal efficacy - 01/1

Dalia Samuel Shaker Kirolos

DS Shaker, S Ismail, S Hamed, EM El-Shishtawy


Terbinafine Hcl (TB) is a poorly water soluble antifungal drug. Topical nanoemulsion based gel containing TB was prepared with a view to improve its solubility and antifungal activity. In preparation of the nanoemulsion (NE), excipients were selected based on the solubility study. Peceol was optimized as the oil phase. Tween 80 and propanol were optimized as the surfactant and co-solvent respectively, and were mixed (Smix) in different weight ratios (1:1, 1:2, 1:3, 1:4, 4:1, 3:1 and 2:1, respectively). Pseudoternary phase diagrams were developed and Pecol and Smix were mixed in different weight ratios ranging from 1:9 to 9:1. Based on the NE region of each diagram, the formulae were selected. The formulated nanoemulsions were characterized and evaluated for in vitro drug release and thermodynamic stability. The optimum nanoemulsion formulae containing 10 or 15% w/w oil, 45% w/w Smix (1:2/1:3) and 45-40% w/ w aqueous phase) were incorporated into Carbopol 940 gel bases forming three different TB nanoemulsion based emulgel formulae (F1-F3) which were examined for ex vivo drug permeation and in vivo antifungal activity compared to the marketed product; Lamisil® emulgel. The results showed that TB skin permeation from all the prepared nanoemulsion based gel formulae was significantly (p < 0.05) improved in relation to the commercial emulgel. F3 exhibited a superior in vivo antifungal activity over the marketed emulgel for the treatment of Candida infection.

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Enhanced Transdermal Permeability of Terbinafine through Novel Nanoemulgel Formulation; Development, In vitro and In vivo Characterization - 01/0

Dalia Samuel Shaker Kirolos

Maha E. Elmataeeshy , Magda S. Sokar , Mohamed Bahey El-Din , Dalia S. Shaker.


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Development of novel immobilized catalase delivery system through nanoencapsulation in Brij® niosomes. - 01/0

Dalia Samuel Shaker Kirolos

.Heidi M. Abdel-Mageed, Afaf S. Fahmy, Dalia S. Shaker, Saleh A. Mohamed.


One of the main challenges for successful pharmaceutical application of Catalase (CAT) is maintaining its stability. Physical immobilization of CAT through nano-encapsulation was proposed to resolve this challenge. CAT encapsulating niosomes (e-CAT) were prepared using different types of Brij® in presence of cholesterol (Ch). Kinetic parameters, pH optimum, thermal stability and reusability of CAT were determined. Results revealed that encapsulation enhanced CAT catalytic efficiency (Vmax/ Km). Free CAT and e-CAT had pH optimum at 7.0. e-CAT exhibited improved thermal stability where it retained 50% residual activity at 60 ◦C. Free CAT lost its activity after 3 consecutive operational cycles however, e-CAT retained 60% of its initial activity following 12 cycles. Based on these encouraging results, CAT immobilization demonstrated a promising novel delivery system that enhances its operational stability.

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Award Donor Date
Editorial Board member of Future Journal of Pharmaceutical Sciences, Elsevier FUE 2015
AAPS membership AAPS organization, USA 2000

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