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Staff Researches

Amr Maged Ibrahim Abdelbaky

Hydroxypropyl-beta-cyclodextrin as cryoprotectant in nanoparticles prepared by nano-spray drying technique

Amr Maged Ibrahim Abdelbaky

Azza Mahmoud, Mahmoud Ghorab

International Conference on Nanomedicine and Nanobiotechnology 2017, Barcelona

2017

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Hydroxypropyl-Beta-Cyclodextrin as Cryoprotectant in Nanoparticles Prepared By Nano-Spray Drying Technique

Amr Maged Ibrahim Abdelbaky

Azza A. Mahmoud, Mahmoud M. Ghorab

Journal of Pharmaceutical Sciences & Emerging Drugs

2017

Nano-spray dryer is advanced instrument to produce a stable and spherical nanoparticles with high yield. In this study, econazole nitrate nanoparticles were formulated by nano-spray dryer using 1:1, 1:2 and 1:3 weight ratios of drug to hydroxypropyl-beta-cyclodextrin and stabilizer. The prepared samples were sprayedthrough nozzle size of 7.0 μm using 95ºC and 45ºC as inlet temperature and outlet temperatures, respectively. The prepared nanoparticles were evaluated for process yield and percent drug loading. Furthermore, the drug nanoparticles were dispersed in isotonic buffer solution and examined for drug release and their stability at room temperature. The spray dried particles were in the nano-range (148 to 294 nm) and their yield values ranged between 79.1 and 84.9 %. Increasing weight ratio of drug to hydroxypropyl-beta-cyclodextrin to 1:2 and 1:3 showed increases in percent drug release compared to formulation containing 1:1 weight ratio of drug to hydroxypropyl-beta-cyclodextrin. On the other hand, the prepared econazole nitrate nanosuspension containing 1:1 weight ratio of drug to hydroxypropyl-beta-cyclodextrin revealed best stability study during storage period at room temperature compared to other formulations. As a result of in-vitro drug release and stability studies, the optimum weight ratio of 1:1, drug to hydroxylpropyl-beta-cyclodextrin was chosen as a best weight ratio duo to its good balance between drug release and stability of drug loaded nanoparticles

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Design and Evaluation of Econazole Nitrate Nanoparticles

Amr Maged Ibrahim Abdelbaky

Azza A. Mahmoud, Mahmoud M. Ghorab

Faculty of Pharmacy, Cairo University

2016

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Nano Spray Drying Technique as a Novel Approach To Formulate Stable Econazole Nitrate Nanosuspension Formulations for Ocular Use

Amr Maged Ibrahim Abdelbaky

Azza A. Mahmoud, Mahmoud M. Ghorab

Molecular Pharmaceutics

2016

The effect of using methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin as carriers for econazole nitrate nanoparticles prepared by nano spray dryer was explored in this work. Stabilizers, namely, poly(ethylene oxide), polyvinylpyrrolidone k30, poloxamer 407, Tween 80, and Cremophor EL, were used. The nano spray dried formulations revealed almost spherical particles with an average particle size values ranging from 121 to 1565 nm and zeta potential values ranging from −0.8 to −2.5 mV. The yield values for the obtained formulations reached 80%. The presence of the drug in the amorphous state within the nanosuspension matrix system significantly improved drug release compared to that for pure drug. Combination of hydroxypropyl-β-cyclodextrin with Tween 80 achieved an important role for preserving the econazole nanosuspension from aggregation during storage for one year at room temperature as well as improving drug release from the nanosuspension. This selected formulation was suspended in chitosan HCl to increase drug release and bioavailability. The in vivo evaluation on albino rabbit’s eyes demonstrated distinctly superior bioavailability of the selected formulation suspended in chitosan compared to its counterpart formulation suspended in buffer and crude drug suspension due to its mucoadhesive properties and nanosize. The nano spray dryer could serve as a one step technique toward formulating stable and effective nanosuspensions.

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Stability and in-vitro drug release studies for nanoparticles prepared by nano-spray drying technique

Amr Maged Ibrahim Abdelbaky

Azza A. Mahmoud, Mahmoud M. Ghorab

FUE International Conference of Pharmaceutical Sciences, Cairo

2017

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Design of rosuvastatin calcium scaffolds for wound healing

Amr Maged Ibrahim Abdelbaky

Abdelfattah A. Abdelkhalek, Azza A. Mahmoud, Salwa Salah, Mahmoud M. Ghorab

5th FUE International Conference for Pharmaceutical Sciences

2019

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Mesenchymal stem cells associated with chitosan scaffolds loaded with rosuvastatin to improve wound healing

Amr Maged Ibrahim Abdelbaky

Abdelfattah A.Abdelkhalek, Azza A. Mahmoud, Salwa Salah, Mohamed M. Ammar, Mahmoud M. Ghorab

European Journal of Pharmaceutical Sciences

2019

In this study we explored the role of rosuvastatin calcium in skin regeneration as statins play important role in the field of tissue engineering. Chitosan hydrochloride was crosslinked with different weight ratios of collagen, β-glycerolphosphate and carboxymethyl cellulose to produce scaffolds by lyophilization technique. Subsequently, the fabricated scaffolds were examined for their morphology, water absorption capacity, water retention, friability and in-vitro drug release as well as in-vivo studies. The results revealed porous 3-D structured scaffolds with maximum water absorption values-ranging between 396 and 2993%. Scaffolds containing carboxymethyl cellulose revealed highest water absorption-values. In-vitro drug release results showed gradual drug release for 60 h with mean dissolution time-values (MDT) between 13 and 21 h. Combination of chitosan, collagen, carboxymethyl cellulose in weight ratio of 40:30:30, respectively achieved gradual disintegration of the scaffold in a simulating medium to an open wound after 4 days. This selected scaffold loaded with rosuvastatin revealed increase proliferation of human dermal fibroblasts compared to placebo scaffold. After 30 days of implantation of selected medicated scaffold loaded with/without mesenchymal stem cells and placebo scaffolds to induced wounds in Albino rats, enhanced skin regeneration and absence of scar formation for drug loaded scaffolds were observed. The histopathological study showed the advantage of stem cells-loaded scaffolds through the normal redistribution of collagen in the epidermal layer. In conclusion, rosuvastatin calcium and stem cells loaded in the tested scaffolds proved their potential effect in enhancing skin healing and regeneration.

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