Future University In Egypt (FUE)

Staff Research

Paper Title :
Author : Salwa Abdelwahhab
CoAuthors : Galal A. Elsayed1, Mohammad E. Azab1, Salwa S. Abdel-Wahab2
Source : J. Heterocyclic Chemestry
Date of Publication :
Abstract : Due to the remarkable pharmacodynamics and chemotherapeutics activities of thiadiazolopyrimidines, A new series of 1,3,4-thiadiazolo[3,2-a] pyrimidine derivatives have been synthesized by reacting 5-substituted-2-aminothiadiazoles 1a,b with different reagents; active methylenic compounds, benzaldehyde under different conditions, isatin, and cyclic ketones. The structures of the novel compounds have been inferred by spectroscopic methods (IR, 1H-NMR, 13C-NMR, MS), and elemental analyses. The newly synthesized compounds were screened against four bacterial strains (Staphylococcus aureus and Listeria monocytogenes as Gram positive; Pseudomonas aeruginosa and Salmonella typhimurium as Gram negative) and two Fungi (Aspergillus Niger and Candida Albicans) using agar diffusion assay. Most of the compounds showed activity against the tested microorganisms with different extents. The in-vitro anticancer activities of these compounds were assessed against four human tumor cell lines, they were found to exhibit different cytotoxic effects. Such results mean that these derivatives can be further utilized as promising anticancer agents.
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